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Induction and suppression of Haemaphysalis longicornis ticks antiviral RNA interference responses by arthropod-borne RNA viruses (RNA-Seq)

ABSTRACT: Induction and suppression of Haemaphysalis longicornis ticks antiviral RNA interference responses by arthropod-borne RNA viruses (RNA-Seq)

PROVIDER: PRJNA693335 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13486386_1.fastq.gz	Fastqsanger.gz
	SRR13486386_2.fastq.gz	Fastqsanger.gz
	SRR13486387_1.fastq.gz	Fastqsanger.gz
	SRR13486387_2.fastq.gz	Fastqsanger.gz
	SRR13486388_1.fastq.gz	Fastqsanger.gz

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Induction and suppression of Haemaphysalis longicornis ticks antiviral RNA interference responses by arthropod-borne RNA viruses (RNA-Seq)

Project description:Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe clinical symptoms and mortality in humans. Haemaphysalis longicornis tick has been identified as the competent vector for SFTSV transmission. Although antiviral RNA interference (RNAi) in insects has been well documented, the degree to which RNAi contributes to antiviral defense in ticks is still largely elusive. In this study, utilizing arthropod-borne RNA viruses, including SFTSV, we find abundant virus-derived small interfering RNAs (vsiRNAs) are induced in H. longicornis after infection through either microinjection or natural blood-feeding. Furthermore, we identify a Dicer2-like homolog, the core protein of antiviral RNAi pathway, in H. longicornis and knocking down this gene exacerbated virus amplification. To counteract this antiviral RNAi of ticks, viruses have evolved suppressors of RNAi (VSRs). Here, we show that reduced viral replication inversely correlated with the accumulation of vsiRNAs in ticks after infection with recombinant sindbis virus (SINV) expressing heterologous VSR proteins. Elucidating the antiviral RNAi pathway of ticks by model arthropod-borne RNA viruses in vivo is critical to understanding the virus-host interaction, providing a feasible intervention strategy to control tick-borne arbovirus transmission.

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