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Effect of the Foxp3 inhibitory peptide P60 on gene array expression of Karpas cell line

ABSTRACT: Effect of the Foxp3 inhibitory peptide P60 on gene array expression of Karpas cell line

PROVIDER: PRJNA693835 | ENA |

REPOSITORIES: ENA

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Effect of the Foxp3 inhibitory peptide P60 on gene array expression of Karpas cell line

Project description:By using a phage displayed peptide library we identified peptide P60 as able to bind Foxp3 and inhibit Treg activity. To gain insight into the effect of P60 in Foxp3+ve cells we used Karpas 299 human cell line derived from a human lymphoma with a regulatory T cell profile. Microarray analysis of Karpas cell line incubated with or without P60 peptide was carried out using the Affymetrix human U133 Plus 2.0 array.

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