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Chromatin accessibility landscape of freshly-isolated human and murine muscle satellite cells and myoblasts

ABSTRACT: Chromatin accessibility landscape of freshly-isolated human and murine muscle satellite cells and myoblasts

PROVIDER: PRJNA694556 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13518716_1.fastq.gz	Fastqsanger.gz
	SRR13518716_2.fastq.gz	Fastqsanger.gz
	SRR13518717_1.fastq.gz	Fastqsanger.gz
	SRR13518717_2.fastq.gz	Fastqsanger.gz
	SRR13518719_1.fastq.gz	Fastqsanger.gz

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Chromatin accessibility landscape of freshly-isolated human and murine muscle satellite cells and myoblasts

Project description:Muscle stem cells, also known as satellite cells, represent the main myogenic population accounting for skeletal muscle homeostasis and regeneration. Here, using the Assay for Transposase Accessible Chromatin followed by sequencing (ATAC-seq), we investigated the epigenetic landscape of activated human and murine satellite cells. Our analysis identified a compendium of putative regulatory elements defining activated satellite cells and myoblasts, respectively.

2021-08-20 | GSE165414 | GEO

Expression data from freshly isolated murine muscle satellite cells

Project description:Expression data from freshly isolated murine muscle satellite cells

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Transcription profiling of mouse muscle satellite cell-derived myoblasts (MyoD-/-, p53-/-)

Project description:Muscle satellite cells are a self-renewing pool of stem cells that give rise to daughter myogenic precursor cells in adult skeletal muscle. Published and preliminary data indicated that MyoD and p53 genes are involved in satellite cell differentiation. We would like to know what downstream genes of both transcription factors are affected in satellite cell-derived myoblasts (MyoD-/-, p53 -/-). Experiment Overall Design: this experiment include 3 samples and 25 replicates

2008-06-12 | E-GEOD-3244 | biostudies-arrayexpress

Microarray analysis of gene expression regulation by Vgll3 in mouse satellite cell-derived myoblasts

Project description:Hippo effectors Yap and Taz, Vgll1-4 and Tead 1-4 transcription factors have been linked to satellite cell/ myoblast proliferation and differentiation, muscle function and disease. The molecular function of Vgll3 in skeletal muscle stem cells was investigated using analysis of gene expression by microarrays to determine Vgll3 mediated gene expression changes and compare those to previously determined Taz and Yap mediated changes. Satellite cell-derived myoblasts were transduced with Vgll3 retrovirus for 24h or 48h, with empty retrovirus vector as control. Triplicate microarray analysis of empty vector controls and Vgll3 transgenic primary myoblasts were conducted.

2019-06-17 | E-MTAB-7614 | biostudies-arrayexpress

Cells isolated from diaphragm of mdx mouse: satellite cells vs. PDGFRa+ cells

Project description:Transcriptional profiling of mouse skeletal muscle-derived cells comparing satellite cells with PDGFRa+ cells. Satellite cells and PDGFRa+ cells were directly isolated from diaphragm of dystrophic mdx mouse by FACS. Two-condition experiment, satellite cells vs. PDGFRa+ cells. Freshly isolated. One replicate per array.

2011-12-08 | E-GEOD-25258 | biostudies-arrayexpress

Muscle Satellite Cells: MyoD and p53 genes

2005-09-07 | GSE3244 | GEO

ChIP-seq of GATA4 in mouse skeletal muscle myoblasts

Project description:GATA4 occupancy on the mouse genome of satellite cell-derived primary myoblasts. Proliferating myoblasts cultured in growth medium were immunoprecipitated with anti-GATA4 antibody or control IgG. Precipitated genomic DNAs were subjected to next generation sequencing. Paired-end 150 bp sequence reads of GATA4-ChIP and IgG-ChIP using mouse skeletal muscle myoblasts.

2015-04-10 | E-GEOD-67703 | biostudies-arrayexpress

ChIP-seq of GATA4 in mouse skeletal muscle myoblasts

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Skeletal muscle satellite cells, endothelial cells and single muscle fibers

Project description:There is considerable crosstalk between satellite cells, endothelilal cells and muscle fibers. Transcriptome analysis from freshly isolated cells from each compartment should help elucidate these pathways.

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Transcription profiling of mouse satellite cells isolated from skeletal muscle

Project description:(Abstract of publication submitted currently) To clarify molecular regulation of satellite cells, we performed genome-wide gene expression analysis of quiescent satellite cells isolated from mouse skeletal muscle by flow cytometry. We identified 53 novel quiescent satellite cell-specific genes whose expressions are sharply down-regulated upon activation. The gene list contains a number of cell surface molecules, transcriptional factors, and cytokines and other signal transduction molecules. We further confirmed that Odz4 and calcitonin receptor proteins were expressed by quiescent but not by activated satellite cells in vivo. Importantly, we found that Pax7+/calcitonin receptor+ satellite cells reappear in close association with regenerating myofibers 7 days after muscle damage, often outside the basal lamina. Moreover, an agonist of calcitonin receptor suppressed the activation of quiescent satellite cells on myofibers in in vitro culture, suggesting that calcitonin receptor signaling plays an important role in renewal and maintenance of satellite cells. Our results show the gene expression profile of quiescent satellite cells for the first time and reveal the temporal and spatial reappearance of a satellite cell pool. Experiment Overall Design: Satellite cells and non-satellite cells were examined. Totally three types of cells (groups), the satellite cells in quiescent and activated states and the non-satellite cells, were compared. Each has 4 replicates.

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