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Transcriptional effects of YAP/TAZ knockdown in human fibroblasts

ABSTRACT: Transcriptional effects of YAP/TAZ knockdown in human fibroblasts

PROVIDER: PRJNA695284 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13565829.fastq.gz	Fastqsanger.gz
	SRR13565830.fastq.gz	Fastqsanger.gz
	SRR13565831.fastq.gz	Fastqsanger.gz
	SRR13565832.fastq.gz	Fastqsanger.gz
	SRR13565833.fastq.gz	Fastqsanger.gz

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Transcriptional effects of YAP/TAZ knockdown in fibroblasts

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Project description:The Hippo pathway plays a crucial in organ size control during development and tissue homeostasis in adult life. To examine a role for Hippo signaling in the intestinal epithelium, we analyzed gene expression patterns in the mouse intestinal epithelilum transfected with siRNAs or expression plasmids for shRNAs targeting the Hippo pathway effectors, YAP and TAZ. We performed two independent series of experiments (siGFP (n=3) vs siYAP/siTAZ (n=3), and shLacZ (n=1) vs shYAP/shTAZ (n=1)). Control siRNA (siGFP), YAP/TAZ siRNAs, or expression plasmids for control shRNA (shLacZ) or YAP/TAZ shRNAs were introduced into the mouse intestinal epithelium by the newly-developed in vivo transfection method. Four days after transfection, intestinal epithelial cells were isolated from the tissues and total RNA was extracted.

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