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Comparison of transcriptional profiles of (1) intestinal ILC3s isolated from WT and IL-17D-deficient mice (2) CD93+ILC3s and CD93-ILC3s from WT mice

ABSTRACT: Comparison of transcriptional profiles of (1) intestinal ILC3s isolated from WT and IL-17D-deficient mice (2) CD93+ILC3s and CD93-ILC3s from WT mice

PROVIDER: PRJNA697917 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13577646_1.fastq.gz	Fastqsanger.gz
	SRR13577646_2.fastq.gz	Fastqsanger.gz
	SRR13577647_1.fastq.gz	Fastqsanger.gz
	SRR13577647_2.fastq.gz	Fastqsanger.gz
	SRR13577648_1.fastq.gz	Fastqsanger.gz

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Comparison of transcriptional profiles of (1) intestinal ILC3s isolated from WT and IL-17D-deficient mice; (2) CD93+ILC3s and CD93-ILC3s from WT mice

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Project description:Purpose: The goal of this study was to compare the transcriptome of FACS-purified bone marrow BL/6 (WT) or CD93-/- (KO) LSKs and BL/6 (WT) or CD93-/- (KO) LSCs. We also compared the transcriptome of FACS-purified bone marrow LSCs isolated from BL/6 mice previously treated with MCP or Veh in vivo. Methods: Transcriptomic analysis of CD93-proficient and deficient bone marrow LSKs and CML LSCs or CML LSCs upon treatment with MCP or Veh, were assessed in biological replicates using Illumina. qRT–PCR validation was performed using SYBR Green assays. Results: We mapped around 30 million sequence reads per sample to the mouse genome (GRCm38 - mm10) and identified expressed transcripts in studied samples. RNA-seq data confirmed stable expression of known housekeeping genes. Differentially expressed genes among conditions were identified with a fold change ≥1.5 and FDR p-value <0.05. Conclusions: Our study represents the first detailed transcriptome analysis of CD93-proficient and deficient bone marrow LSKs and LSCs isolated from BM of naïve and CML mice generated by RNA-seq. technology. Our results show that CD93-signaling triggers stem cell maintenance- and cell proliferation-promoting signaling pathways in CML LSCs. In addition, we showed transcriptome analysis of FACS-purified bone marrow LSCs isolated from BL/6 (WT) mice which were previously treated with MCP or Veh in vivo. Our results show that MCP treatment suppresses the stem cell maintenance- and cell proliferation-promoting signaling pathways in CML LSCs.

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Analyses of ILC3s from the mesenteric lymph nodes (LN)

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