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Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1

ABSTRACT: Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1

PROVIDER: PRJNA697957 | ENA |

REPOSITORIES: ENA

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Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1

Project description:We identified the Igfbpl1 gene by RNAseq of the neural precursor cells (NPCs) of the mice subventricular zone (SVZ), as an important gene released by SVZ-NPCs that play an important role in control of the striatal homeostasis and in particular involved in the cognitive processes and decision-making.

2022-12-08 | GSE165815 | GEO

Probiotic administration effect on microbiome composition, emotional memory and decision-making

Project description:Probiotic administration effect on microbiome composition, emotional memory and decision-making

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microRNA signature to support clinical-decision making in patients with suspected Obstructive Sleep Apnea

Project description:microRNA signature to support clinical-decision making in patients with suspected Obstructive Sleep Apnea

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Decision Aid to Technologically Enhance Shared Decision Making

Project description:Physicians face a challenge in promoting colorectal cancer screening (CRCS) in the face of multiple competing demands. A decision aid (DA) that clarifies patient preferences and improves decision quality could aid shared decision making (SDM) and be effective at increasing CRCS rates. However, exactly how such DA improves SDM is not clear. This 4-year R01 study funded by the National Cancer Institute seeks to provide detailed understanding of how an interactive DA affects patient-physician communication and SDM, and ultimately CRCS adherence.

| 2118961 | ecrin-mdr-crc

Shared Decision-Making for Colorectal Cancer Screening

Project description:The overall objective of this study is to conduct a three-arm randomized controlled trial to evaluate the impact of an interactive, web-based decision aid on shared decision-making and patient adherence to colorectal cancer (CRC) screening recommendations.

| 2023381 | ecrin-mdr-crc

Online Trial Examining Validity of the Shared Decision Making Process Survey With Video Vignettes

Project description:This study will recruit subjects online and randomly assigned them to one of four arms. The arms vary by clinical decision (colorectal cancer screening or treatment of high cholesterol) by video order (poor shared decision making followed by good or good shared decision making followed by poor). Participants will view two videos and complete the Shared Decision Making process survey along with a few other measures after each video. Our main hypothesis is that respondents watching the good shared decision making videos will score higher on the Shared Decision Making Process survey compared to those watching the poor videos.

| 2333773 | ecrin-mdr-crc

Colorectal Cancer Screening With Improved Shared Decision Making

Project description:The purpose of this study is to increase colorectal cancer screening by implementing a community-wide shared decision-making (SDM) intervention, which embeds shared decision making within clinical practice and also uses an extensive community engagement campaign. The investigators hypothesize that colorectal cancer screening adherence will be higher in the intervention group (participating communities) compared to the usual care control group (non-participating comparison communities).

| 2119361 | ecrin-mdr-crc

Proteome integral solubility alteration assay combined with multi-criteria decision-making analysis for developing adverse outcome pathways

Project description:To simplify chemical risk assessment, the adverse outcome pathway (AOP) method has arisen as a framework to predict the impact of chemical exposure on human and environmental health. The development of this predictive tool requires knowledge of the molecular interaction between chemicals and protein targets. Here, we demonstrate that the identification and selection of a target candidate to develop adverse outcome pathways can be obtained by applying high-throughput identification of chemical targets by proteome integral solubility alteration (PISA) assay, followed by selecting the priority target candidate by an analytical hierarchy process. From 8 identified protein targets for TCDD from a soluble proteome extracted from hepatocytes, we selected the priority target for developing AOPs. Our combined methodologies provide identification of a molecular initiating event, essential knowledge to link molecular interaction to impact on health. The identification of chemical targets following a systematic analysis of chemical protein interaction by proteomics increases the high-throughput and reduces the traditional bias. The target selection eliminates conflicting criteria by applying a multiple-criteria decision-making analysis.

2023-03-11 | PXD033056 | Pride

Utilizing single-cell variations to reveal environment-dependent tuning of network connectivity in human macrophages

Project description:Utilizing single-cell variations to reveal environment-dependent tuning of network connectivity in human macrophages

| PRJNA321546 | ENA

Risk Stratification to Promote Effective Shared Decision-Making for Colorectal Cancer Screening

Project description:Shared decision-making (SDM) has been advocated as a strategy for increasing colorectal cancer (CRC) screening rates. Our studies to date suggest that while the use of a novel computer-based decision aid facilitates several components of SDM from both the patient and provider perspective, there is a reluctance among providers to acquiesce to patient preferences for a particular screening strategy when its differs from their own. The overall objective of this study is to assess whether risk stratification for advanced colorectal neoplasia influences clinical decision-making related to screening test selection and adherence within a SDM framework. Eligible subjects will be randomized to either an experimental arm, in which they will be asked to complete a 6-item risk assessment questionnaire known as the "Advanced Colorectal Neoplasia Index [ACNI]" after reviewing a web-based decision aid, or a control arm, in which they will only review the decision aid. Both interventions will take place just before a prearranged office visit with their provider. The primary outcome will be screening test ordered; secondary outcomes will include test completion rates, concordance between test preference and test ordered,, patient satisfaction with decision-making process, screening intentions, 6-month test completion rates and provider satisfaction. Outcomes will be evaluated using computerized tracking systems or validated instruments.

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