Project description:Rhizopus delemar is an invasive fungal pathogen, responsible for the frequently fatal disease mucormycosis. Germination, a crucial mechanism by which spores of Rhizopus delemar infect and cause disease, is a key developmental process that transforms the dormant spore state into a vegetative one. Understanding the molecular mechanisms which underpin this transformation may be key to controlling mucormycosis; however, the regulation of germination remains poorly understood. This study describes the transcriptional changes which take place over the course of germination.
Project description:The R. delemar strain ATCC 20344 was cultured under nitrogen starvation conditions with varied oxygen availability to induce high (aerobic) and low (anaerobic) fumarate production.
