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RNA-Seq transcriptome profiling of human iPS cell-derived cardiomyocytes (hiPSC-CMs) following overexpression (OE) of estrogen-related receptor gamma (ERRg)

ABSTRACT: RNA-Seq transcriptome profiling of human iPS cell-derived cardiomyocytes (hiPSC-CMs) following overexpression (OE) of estrogen-related receptor gamma (ERRg)

PROVIDER: PRJNA698780 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13609000.fastq.gz	Fastqsanger.gz
	SRR13609001.fastq.gz	Fastqsanger.gz
	SRR13609002.fastq.gz	Fastqsanger.gz
	SRR13609003.fastq.gz	Fastqsanger.gz
	SRR13608992.fastq.gz	Fastqsanger.gz

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RNA-Seq transcriptome profiling of human iPS cell-derived cardiomyocytes (hiPSC-CMs) following overexpression (OE) of estrogen-related receptor gamma (ERRg)

Project description:Transcriptional regulatory circuits that drive cardiomyocyte maturation are poorly understood. Human iPS cell-derived cardiomyocytes (hiPSC-CMs) have been shown to have fetal cardiomyocyte features in terms of metabolic gene expression profiles. Here we found that in hiPSC-CMs, overexpression of estrogen-related receptor gamma (ERRg) is sufficient to drive cardiomyocyte metabolic maturation programs including the induction of a number of oxidative mitochondrial metabolic genes.

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