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Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts.

ABSTRACT: Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts.

PROVIDER: PRJNA698943 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10735573.fastq.gz	Fastqsanger.gz
	SRR10735574.fastq.gz	Fastqsanger.gz
	SRR10735575.fastq.gz	Fastqsanger.gz
	SRR10735576.fastq.gz	Fastqsanger.gz
	SRR10735577.fastq.gz	Fastqsanger.gz

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Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts [scRNA-seq]

Project description:Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts [scRNA-seq]

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Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts [bulk RNA-seq]

Project description:Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts [bulk RNA-seq]

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Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts [scRNA-seq]

Project description:Glial progenitor cells (GPCs), the primary source of oligodendrocytes and astrocytes in the human CNS, emerge during the 2nd trimester of human development and subsequently colonize the brain, where a pool remains throughout adulthood. While fetal GPCs are highly migratory and proliferative, there is evidence that their capacities diminish throughout aging or as a result of demyelination-induced exhaustion, thus compromising their ability to mobilize, remyelinate, and self-renew. To investigate this mechanism, we first utilized bulk and scRNA-Sequencing to characterize the human fetal GPC pool and leveraged these data to elucidate transcriptional discrepancies in adult human GPCs. This revealed age-induced transcriptional shifts towards loss of proliferative competency and the potential onset of senescence. Further, we inferred adult networks of direct repressive transcription factor activity that may drive functional decline during GPC aging. Finally, we coupled these data with miRNA profiling of both populations to establish both upstream and parallel arms of repression that may stifle the functional aptitude of aged GPCs. These identified upstream regulators may be ideal therapeutic targets toward rejuvenating GPCs crippled by mitotic exhaustion or aging.

2024-01-29 | GSE165995 | GEO

Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts [bulk RNA-seq]

2023-08-28 | GSE165994 | GEO

Human Adult Glial Progenitors Express Distinct miRNA Profiles Compared to their Fetal Counterparts

Project description:Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we identify age-related changes in transcription consistent with the repression of genes enabling mitotic expansion, concurrent with the onset of aging-associated transcriptional programs. Adult hGPCs develop a repressive transcription factor network centered on MYC, and regulated by ZNF274, MAX, IKZF3, and E2F6. Individual over-expression of these factors in iPSC-derived hGPCs lead to a loss of proliferative gene expression and an induction of mitotic senescence, replicating the transcriptional changes incurred during glial aging. miRNA profiling identifies the appearance of an adult-selective miRNA signature, imposing further constraints on the expansion competence of aged GPCs. hGPC aging is thus associated with acquisition of a MYC-repressive environment, suggesting that suppression of these repressors of glial expansion may permit the rejuvenation of aged hGPCs.

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Human Adult Glial Progenitors Are Transcriptionally Distinct from Their Fetal Counterparts.

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-08-29 | GSE165996 | GEO

RNAseq Data of Neural Stem Cells, Glial progenitors and Sox1 positive Glial progenitors

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ATAC-Sequencing of human fetal PreProB and ProB progenitors.

Project description:Human lymphopoiesis is a dynamic life-long process that starts in utero at 6 weeks gestation; however developmental pathways defining fetal lymphopoiesis are largely unexplored. While the first committed B-progenitor in normal human bone marrow (BM) is a CD10+ve ProB-progenitor, the identification of a CD10-ve B-progenitor (Pre/ProB progenitor) in cord blood suggests there may be a second B-lymphoid development program in fetal life. Here, we provide a comprehensive analysis of the fetal B-cell developmental hierarchy and report the presence of both PreProB- and ProB-progenitors in fetal tissues and describe their ontogeny, molecular and functional characteristics. PreProB- and ProB-progenitors appear early in the first trimester in fetal liver, followed by a sustained second wave of B-progenitor development in fetal BM, where together they form >40% of the total HSC/progenitor pool. Unexpectedly, one-third of the B-progenitors (13±1% of lin-CD34+ cells) are CD10-ve PreProB-progenitors while, by contrast, PreProB-progenitors are virtually undetectable in adult BM. Single-cell transcriptomics and functional assays place PreProB- upstream of ProB-progenitors, identifying them as the first B-lymphoid restricted progenitor in human fetal life. Fetal BM PreProB- and ProB-progenitors both give rise solely to B-lineage cells yet they are transcriptionally distinct. PreProB- unlike ProB-progenitors, continue to express a number of key myeloid and stem cell genes and share some transcriptomic signatures with CD10-ve B-progenitor infant acute lymphoblastic leukemia blast cells. Our data identify PreProB-progenitors as the earliest B-lymphoid restricted progenitor in human fetal life, and suggest that this fetal-restricted committed B-progenitor might provide a permissive cellular context for prenatal B-progenitor leukemia initiation.

2019-08-06 | GSE122989 | GEO

Microarray evaluation of in vitro cultured Sox9+ mouse lung progenitors isolated from E12.5 embryonic lung progenitors

Project description:The study aims to show that Sox9+ Chd1+ mouse embryonic lung progenitors can be isolated and expanded long-term in 3D culture while maintaining their multipotency. in vitro cultured Sox9+ Chd1+ lung progenitors transcriptionally resemble their in vivo counterparts and show significant difference from adult lung epithelial (Cdh1+ and EpCAM+) and non-epithelial (Cdh1- and EpCAM-) cells

2017-11-01 | E-MTAB-6086 | biostudies-arrayexpress

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