Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Intestinal flora sequencing of mice

PROVIDER: PRJNA699424 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13735614_1.fastq.gz	Fastqsanger.gz
	SRR13735614_2.fastq.gz	Fastqsanger.gz
	SRR13735615_1.fastq.gz	Fastqsanger.gz
	SRR13735615_2.fastq.gz	Fastqsanger.gz
	SRR13735616_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Project description:Mice intestinal flora sequencing

| PRJNA705824 | ENA

Project description:mice intestinal flora

| PRJNA739479 | ENA

Polysaccharides from Sargassum fusiforme protect mice against Citrobacter rodentium infection through intestinal microbiota-drived microRNA-92a-3p

Project description:To explore the regulatory mechanism of intestinal flora in Citrobacter rodentium -induced intestinal infection by transcriptome analysis at miRNA molecular level.

2024-03-04 | GSE260446 | GEO

Project description:Intestinal flora of mice

| PRJNA1075476 | ENA

Project description:intestinal flora in mice

| PRJNA867126 | ENA

Project description:Intestinal flora in mice

| PRJNA786260 | ENA

Therapeutic Effects of Valeriana jatamansi on Ulcerative Colitis: Insights into Mechanisms of Action through Metabolomics and Microbiome Analysis

Project description:Ulcerative colitis (UC), belonging to inflammatory bowel disease (IBD), is a chronic and relapsing inflammatory disorders of the gastrointestinal tract, which is not completely cured so far. Valeriana jatamansi is a Chinese medicine used clinically to treat "diarrhea", which is closely related to UC. This study was to elucidate the therapeutic effects of V. jatamansi extract (VJE) on dextran sodium sulfate (DSS)-induced UC in mice and its underlying mechanism. In this work, VJE effectively ameliorate the symptoms, histopathological scores and reduce the production of inflammatory factors of UC mice. The colon untargeted metabolomics analysis and 16S rDNA sequencing showed remarkable differences in colon metabolite profiles and intestinal microbiome composition between the control and DSS groups, and VJE intervention can reduce these differences. Thirty-two biomarkers were found and modulated the primary pathways including pyrimidine metabolism, arginine biosynthesis and glutathione metabolism. Meanwhile, twelve significant taxa of gut microbiota were found. Moreover, there is a close relationship between endogenous metabolites and intestinal flora. These findings suggested that VJE ameliorates UC by inhibiting inflammatory factors, recovering intestinal maladjustment, and regulating the interaction between intestinal microbiota and host metabolites. Therefore, the intervention of V. jatamansi is a potential therapeutic treatment for UC.

2023-07-24 | PXD043047 | Pride

Project description:16sRNA sequencing of mice intestinal flora

| PRJNA1025257 | ENA

Project description:intestinal flora in AD mice

| PRJNA1191988 | ENA

Project description:Intestinal flora of mice with colitis

| PRJNA853097 | ENA