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IgG1 Immune Complexes Inhibit Naïve T Cell Proliferation but Stimulate a Subset of Their Progeny

ABSTRACT: IgG1 Immune Complexes Inhibit Naïve T Cell Proliferation but Stimulate a Subset of Their Progeny

PROVIDER: PRJNA700982 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13666869_1.fastq.gz	Fastqsanger.gz
	SRR13666869_2.fastq.gz	Fastqsanger.gz
	SRR13666870_1.fastq.gz	Fastqsanger.gz
	SRR13666870_2.fastq.gz	Fastqsanger.gz
	SRR13666871_1.fastq.gz	Fastqsanger.gz

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IgG1 Immune Complexes Inhibit Naïve T Cell Proliferation but Stimulate a Subset of Their Progeny

Project description:We examined the effects of well-defined, soluble IgG1 immune complexes on the phenotypes of human peripheral naive CD8+ T cells. We demonstrate that IgG1-ICs inhibit the proliferation and differentiation of one subset of naïve T cells but stimulate the division of another naïve-like subset. We utilize RNA-Seq to characterize the inhibited and stimulated T cell subsets.

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