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Contextual cues from cancer cells govern CAF heterogeneity [scRNA-seq]

ABSTRACT: Contextual cues from cancer cells govern CAF heterogeneity [scRNA-seq]

PROVIDER: PRJNA701029 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13670200_1.fastq.gz	Fastqsanger.gz
	SRR13670200_2.fastq.gz	Fastqsanger.gz
	SRR13670300_1.fastq.gz	Fastqsanger.gz
	SRR13670300_2.fastq.gz	Fastqsanger.gz
	SRR13670400_1.fastq.gz	Fastqsanger.gz

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Contextual cues from cancer cells govern CAF heterogeneity

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Project description:Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis.

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Project description:Compare the difference between pairwise aNOF and CAF samples for two patients patient #225: aNOF #225 vs CAF #225 patient #248: aNOF #248 vs CAF #248

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