Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mycobacterium tuberculosis transcriptional response to Bedaquiline

ABSTRACT: Mycobacterium tuberculosis transcriptional response to Bedaquiline

PROVIDER: PRJNA701251 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13678100_1.fastq.gz	Fastqsanger.gz
	SRR13678100_2.fastq.gz	Fastqsanger.gz
	SRR13678101_1.fastq.gz	Fastqsanger.gz
	SRR13678101_2.fastq.gz	Fastqsanger.gz
	SRR13678102_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 54

Similar Datasets

Mycobacterium tuberculosis transcriptional response to Bedaquiline

Project description:The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological states, underlies it’s success in evading the immune system and tolerating antibiotic killing. Drug tolerant phenotypes are a major reason why the tuberculosis (TB) mortality rate is so high, with over 1.8 million deaths annually. To develop new TB therapeutics that better treat the infection (faster and more completely), a systems-level approach is needed to reveal the complexity of network-based adaptations of Mtb. Here, we report the transcriptional response of Mtb to the drug Bedaquiline. We performed transcriptomic sequencing (RNA-seq) on Mtb bacilli at 4, 24, 72 h following exposure to the drug.

2021-12-15 | GSE166546 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Bedaquiline

Project description:Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to bedaquiline, we performed transcriptomics over a time-course on MTB bacilli exposed to the drug.

2016-05-05 | GSE72459 | GEO

Global Gene expression data from Mycobacterium tuberculosis treated with new TB drug named Bedaquiline

Project description:Sirturo or Bedaquiline has been shown to inhibit the ATP synthase of Mycobacterium tuberculosis. We used microarrays to investigate compound-induced gene expression changes in general as well as effects on the transcription of the different ATP synthase genes and other metabolic pathways. Log phase Mycobacterium tuberculosis were cultivated in Middlebrook 7H9 broth and treated with 1 M-BM-5M Bedaquiline. We have extracted RNA from five different time-points after treatment: 0 min (T0), 30 min (T30), 60 min (T60), 180 min (T180) and 360 min (T360).

2014-03-03 | E-GEOD-43749 | biostudies-arrayexpress

Global Gene expression data from Mycobacterium tuberculosis treated with new TB drug named Bedaquiline

2014-03-03 | GSE43749 | GEO

Mycobacterium tuberculosis

Project description:Transcriptional Response of Mycobacterium tuberculosis H37Rv to Bedaquiline

| PRJNA294092 | ENA

Bedaquiline-induced transcriptional response of Mycobacterium smegmatis mc2 155

Project description:Transcriptional profiling of M. smegmatis mc2155 grown on Hartmans de Bont (HdB) supplemented with 0.2% glycerol and 0.05% Tween80 challenged with 2 μg/ml Bedaquiline and Dimethyl sulfoxide (DMSO)

2015-04-06 | GSE59871 | GEO

Mycobacterium tuberculosis transcriptional response to Isoniazid

Project description:Mycobacterium tuberculosis transcriptional response to Isoniazid

| PRJNA694989 | ENA

Mycobacterium tuberculosis transcriptional response to Pretomanid

Project description:Mycobacterium tuberculosis transcriptional response to Pretomanid

| PRJNA695291 | ENA

Mycobacterium tuberculosis transcriptional response to linezolid

Project description:Mycobacterium tuberculosis transcriptional response to linezolid

| PRJNA699888 | ENA

Mycobacterium tuberculosis transcriptional response to Clofazamine

Project description:Mycobacterium tuberculosis transcriptional response to Clofazamine