Project description:Alterations in endoplasmic reticulum (ER) homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus produces glucose metabolism perturbations. However, the neurobiological basis linking hypothalamic ER stress with abnormal glucose metabolism remains unknown. Here we report that genetic and induced models of hypothalamic ER stress are associated with alterations in systemic glucose homeostasis due to increased gluconeogenesis (GNG) independent of body weight changes. Defective alpha melanocyte-stimulating hormone (a-MSH) production underlies this metabolic phenotype, as pharmacological strategies aimed at rescuing hypothalamic a-MSH content reversed this phenotype at metabolic and molecular level. Collectively, our results posit defective a-MSH processing as a fundamental mediator of enhanced GNG in the context of hypothalamic ER stress, and establish a-MSH deficiency in proopiomelanocortin (POMC) neurons as a potential contributor to the pathophysiology of T2D.

2015-06-18 | GSE62263 | GEO

Transcription profiling of mouse lymphoma L5178Y cells treated with Hydroxyurea - ILSI-HESI Genotox Study - Hydroxyurea

Project description:Mouse lymphoma L5178Y cells are treated with Hydroxyurea [CAS:127-07-1;CHEBI:5816] and harvested at 4 and 24 hours for analysis.

2006-02-13 | E-TOXM-6 | biostudies-arrayexpress

Reduced a-MSH underlies hypothalamic endoplasmic reticulum stress-induced hepatic gluconeogenesis

2015-06-18 | E-GEOD-62263 | biostudies-arrayexpress

Tapinella atrotomentosa strain:MSH-12

Project description:Tapinella atrotomentosa MSH-12 genome sequencing

| PRJNA346771 | ENA

Multicenter study to assess the reproducibility of NGS-based bacterial typing

Project description:Multicenter study to assess the reproducibility of NGS-based bacterial typing

| PRJEB15231 | ENA

Pseudomonas aeruginosa MSH-10

Project description:Pseudomonas aeruginosa MSH-10 Genome sequencing and assembly

| PRJNA201849 | ENA

Genome-wide binding of hSTN1 in response to hydroxyurea-induced replication stress

Project description:We find that hSTN1 is preferentially enriched at GC-rich repetitive sequences genome-wide after hydroxyurea treatment. HeLa cells stably expressing myc-tagged hSTN1 were treated with 2 mM hydroxyurea, crosslinked, and ChIP-seq was performed.

2016-08-06 | E-GEOD-82123 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data