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Study of the role of c-Maf in type 2 innate lymphoid cells

ABSTRACT: Study of the role of c-Maf in type 2 innate lymphoid cells

PROVIDER: PRJNA701824 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13708608.fastq.gz	Fastqsanger.gz
	SRR13708609.fastq.gz	Fastqsanger.gz
	SRR13708610.fastq.gz	Fastqsanger.gz
	SRR13708611.fastq.gz	Fastqsanger.gz
	SRR13708612.fastq.gz	Fastqsanger.gz

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Study of the role of c-Maf in type 2 innate lymphoid cells

Project description:Group 2 innate lymphoid cells (ILC2s) are involved in type 2 inflammatory diseases such as allergy. In response to repeated allergen inhalations, lung epithelial cells secrete innate cytokines that activate ILC2s to release interleukin-5 (IL-5) and interleukin-13 (IL-13) resulting in eosinophil infiltration, mucus hyper-production, and airway hyperreactivity. Beside GATA3, very little is known about the role of specific transcription factors in the regulation of ILC2’s function. Here we identify c-Maf as a crucial regulator of ILC2 function and identity. c-Maf deficient ILC2s are impaired in IL-5 and IL-13 production and eosinophil recruitment. Transcriptomic analysis underlined a reduced expression of genes associated with Th2/ILC2 identity and memory development that we confirmed both in mice and human, either in ILC2s engineered to express less c-Maf or in naturally c-Maflow ILC2s from cord blood. Our results indicate that c-Maf is a core node that connects immature to primed/trained ILC2s.

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