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ABSTRACT: Draft genome sequence of Ustilaginoidea virens from North-East plains of India

PROVIDER: PRJNA702270 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13728986_1.fastq.gz	Fastqsanger.gz
	SRR13728986_2.fastq.gz	Fastqsanger.gz
	SRR13728987_1.fastq.gz	Fastqsanger.gz

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Genome-wide mapping of H3K4 tri-methylation in ΔUvkmt2 mutant strain of Ustilaginoidea virens

Project description:Epigenetic modification is important for cellular functions. Trimethylation of histone H3 lysine 4 (H3K4me3), which associates with transcriptional activation, is one of the important epigenetic modifications. In this study, the biological functions of UvKmt2-mediated H3K4me3 modification were characterized in Ustilaginoidea virens, which is the causal agent of the false smut disease, one of the most destructive diseases in rice. Phenotypic analyses of the ΔUvkmt2 mutant revealed that UvKMT2 is necessary for growth, conidiation, secondary spore formation, and virulence in U. virens. Immunoblotting and chromatin immunoprecipitation assay followed by sequencing (ChIP-seq) showed that UvKMT2 is required for the establishment of H3K4me3, which covers 1729 genes of the genome in U. virens. In particular, H3K4me3 modification involves in the transcriptional regulation of conidiation-related and pathogenic genes. The down-regulation of UvHOG1 and UvPMK1 genes may be one of the main reasons for the reduced pathogenicity and stresses adaptability of the ∆Uvkmt2 mutant. Overall, H3K4me3, established by histone methyltransferase UvKMT2, contributes to fungal development, secondary spore formation, virulence, and various stresses response through transcriptional regulation in U. virens.

2022-05-25 | GSE203326 | GEO

Ustilaginoidea virens