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RNAseq analysis of BDAA treatment on YFV infected HEK293 cells

ABSTRACT: RNAseq analysis of BDAA treatment on YFV infected HEK293 cells

PROVIDER: PRJNA706409 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13849346.fastq.gz	Fastqsanger.gz
	SRR13849347.fastq.gz	Fastqsanger.gz
	SRR13849348.fastq.gz	Fastqsanger.gz
	SRR13849349.fastq.gz	Fastqsanger.gz

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RNAseq analysis of BDAA treatment on YFV infected HEK293 cells

Project description:Purpose: to investigate the change in gene expression after BDAA treatment on YFV infected HEK293 cells. Methods: HEK293 cells were cultured; then cells were non-infected/infected with YFV, and then untreat/treat with BDAA. Total RNA were harvested and sent to RNA sequencing. Results: we demonstrated that BDAA treatment of YFV infected HEK293 cells at 18 hpi for 2 h increased expression of a total of 39 cellular genes, 33 of which are inflammatory cytokines, chemokines or ISGs, and the remaining are mostly genes related to NFκB, TNF-α and MAPK signal transduction. Conclusion: BDAA triggers an enhanced activation of RNA sensor-mediated inflammatory cytokine responses, most likely by YFV RNA.

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