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The role of MacroH2A1.2 in cancer (ChIP-Seq)

ABSTRACT: The role of MacroH2A1.2 in cancer (ChIP-Seq)

PROVIDER: PRJNA706651 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13856840_1.fastq.gz	Fastqsanger.gz
	SRR13856840_2.fastq.gz	Fastqsanger.gz
	SRR13856841_1.fastq.gz	Fastqsanger.gz
	SRR13856841_2.fastq.gz	Fastqsanger.gz
	SRR13856842_1.fastq.gz	Fastqsanger.gz

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The role of MacroH2A1.2 in cancer (ChIP-Seq)

Project description:MacroH2A1.2 is a histone variant from H2A family. Expression of macroH2A1.2 is found to be dysregulated in cancer especially lung cancer. However, the role of macroH2A1.2 in lung cancer remains relatively unknown. Our study showed that macroH2A1.2 stabilized FASN expression, increased fatty acid production and hence improved OXPHO activity. As a result, the cancer cells with higher macroH2A1.2 expression were more respiratory active and metastatic.

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Project description:MacroH2A1.2 is a histone variant from H2A family. Expression of macroH2A1.2 is found to be dysregulated in cancer especially lung cancer. However, the role of macroH2A1.2 in lung cancer remains relatively unknown. Our study showed that macroH2A1.2 stabilized FASN expression, increased fatty acid production and hence improved rate of mitochondria respiration. As a result, the cancer cells with higher macroH2A1.2 expression were more metastatic.

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