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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (CUT&RUN)

ABSTRACT: T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (CUT&RUN)

PROVIDER: PRJNA713340 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13927573_1.fastq.gz	Fastqsanger.gz
	SRR13927573_2.fastq.gz	Fastqsanger.gz
	SRR13927574_1.fastq.gz	Fastqsanger.gz
	SRR13927574_2.fastq.gz	Fastqsanger.gz
	SRR13927575_1.fastq.gz	Fastqsanger.gz

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers

Project description:T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (ATAC-Seq)

Project description:We used an integrated genomics approach to profile and characterize the cistrome of TR-beta, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in a normal thyroid cell line. Our data demonstrates that T3 promotes significant shifts in TR-beta genomic occupancy, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers.

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (RNA-Seq)

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (CUT&RUN)

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (RNA-Seq)

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (ATAC-Seq)

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Thyroid Hormone Dependent Transcriptional Programming by TRb Requires SWI/SNF Chromatin Remodelers

Project description:Transcriptional regulation in response to thyroid hormone (3,5,3´-triiodo-L-thyronine, T3) is a dynamic and cell-type specific process that maintains cellular homeostasis and identity in all tissues. However, our understanding of the mechanisms of thyroid hormone receptor (TR) actions at the molecular level are actively being refined. We used an integrated genomics approach to profile and characterize the cistrome of TRb, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in normal human thyroid cells. There are significant shifts in TRb genomic occupancy in response to T3, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers. We further demonstrate selective recruitment of BAF and PBAF SWI/SNF complexes to TRb binding sites, revealing novel differential functions in regulating chromatin accessibility and gene expression. Our findings highlight three distinct modes of TRb interaction with chromatin and coordination of coregulator activity.

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers

Project description:This SuperSeries is composed of the SubSeries listed below.

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Triiodothytonine (T3) response is changed after KLF9 knockdown in HepG2-TRbeta overexpressing cells.

Project description:Analysis of T3 response in HepG2-TRbeta cells transfected with siRNA (siCtrl or siKLF9) at gene expression level.The hypothesis tested in the present study was that TR/KLF9 axis is responsible for many of T3 downstream efects. Results provide information of the changr in T3 response after KLF9 knockdown.response

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