Project description:We report a gene expression data on human serum samples for 312 individuals. By examing individuals of different ages. We can have a better understanding of gene expressions associated with aging.
Project description:We report the results of MIRA-Seq-based high-throughput profiling of the bovine fibroblast methylome from three different individuals at two different ages (5 and 16 months of age) to determine the stability of methylation with age.
Project description:We report the results of MIRA-Seq-based high-throughput profiling of the bovine fibroblast methylome from three different individuals at two different ages (5 and 16 months of age) to determine the stability of methylation with age. Examination of methylation in one cell line (fibroblasts) of three individuals at two ages (5 and 16 months).
Project description:564Igi mice homozygous for knockin alleles of 564 IgH and IgK expressed high levels of autoantibodies and exhibited a high incidence of mature B cell lymphomas. This study was designed to evaluate the gene expression profiles of 564Igi mice with different ages.
Project description:SJL mice spontaneously develop mature B cell lineage lymphomas. These studies were designed to evaluate significant gene expression differences between spleens of control mice that do not develop lymphomas compared to spleens from SJL mice of differeing ages
Project description:We provide the first in vivo evidence of global and local chromatin changes in human aging by analyzing cfDNA from the blood of individuals of different age groups. Our results show that nucleosome signals inferred from cfDNA are consistent with the redistribution of heterochromatin observed in cellular senescence and aging in other model systems. It also revealed age and deteriorating health status correlate with a low-level enrichment of signals from cells in the thyroid gland. In addition, we detected an overall nucleosome loss at several genomic locations, such as transcription start and termination sites, 5’UTR of L1HS retrotransposons and dimeric AluY elements with age.