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The effect of Repeated Social defeat stress (RSD) on transcriptomic profiles of rat heart

ABSTRACT: The effect of Repeated Social defeat stress (RSD) on transcriptomic profiles of rat heart

PROVIDER: PRJNA715487 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14001676.fastq.gz	Fastqsanger.gz
	SRR14001677.fastq.gz	Fastqsanger.gz
	SRR14001678.fastq.gz	Fastqsanger.gz
	SRR14001679.fastq.gz	Fastqsanger.gz
	SRR14001680.fastq.gz	Fastqsanger.gz

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The effect of Repeated Social defeat stress (RSD) on transcriptomic profiles of rat heart

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Project description:This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood monocytes and examined the extent to which these effects were abrogated by the beta-adrenergic antagonist propranolol. Study Type: Risk prediction Gene expression profiling was carried out on peripheral blood monocyte mRNA samples collected from 36 mice randomized to either 6 cycles of repeated social defeat (RSD, n=18) or to parallel home cage control (HCC, n=18) conditions. Within each condition (RSD vs HCC), 9 animals were treated with the beta-adrenergic antagonist propranolol and 9 were treated with an equivalent volume of vehicle. After 6 cycles of RSD or parallel HCC, blood samples were pooled into groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on RNA from approximately 1 million CD11b+ peripheral blood mononuclear cells (i.e., monocytes) which were immunomagnetically isolated by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether treatment with propranolol abrogates these effects.

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