Project description:Hepatocellular carcinoma is a poor prognosis cancer leading to death, with high rate of recurrence after curative therapy. The functions of Covalently closed circular RNA (circRNAs) in HCC recurrence have remained largely unknown. In this study, we generated multi-omics data to explore the circRNAs involving in the HCC recurrence.
Project description:CircRNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular caicinoma(HCC) progression remain insuffuciently elucidated. In this study, we generated the circular RNA expression profile of HCC tissue together with the adjacent normal tissues by high-throughput RNA sequencing.
Project description:Hepatocellular carcinoma is a poor prognosis cancer leading to death, with high rate of recurrence after curative therapy. The functions of Covalently closed circular RNA (circRNAs) in HCC recurrence have remained largely unknown. In this study, we generated multi-omics data to explore the circRNAs involving in the HCC recurrence.
Project description:Hepatocellular carcinoma is a poor prognosis cancer leading to death, with high rate of recurrence after curative therapy. The functions of Covalently closed circular RNA (circRNAs) in HCC recurrence have remained largely unknown. In this study, we generated multi-omics data to explore the circRNAs involving in the HCC recurrence.
Project description:Genome wide DNA methylation profiling of paired adjacent and hepatocellular samples and 8 non-diseased liver samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 12 paired adjacent and 12 hepatocellular samples.