Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Transcriptome and DNA methylation dynamics in the Pacific abalone

PROVIDER: PRJNA717717 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14078124_1.fastq.gz	Fastqsanger.gz
	SRR14078124_2.fastq.gz	Fastqsanger.gz
	SRR14078125_1.fastq.gz	Fastqsanger.gz
	SRR14078125_2.fastq.gz	Fastqsanger.gz
	SRR14078126_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Haliotis discus hannai

Project description:Pacific abalone Thermal Adaptation

| PRJNA607433 | ENA

Project description:Gut microbiota of Pacific abalone and a hybrid abalone

| PRJNA530882 | ENA

Project description:Pacific abalone poplation whole genome sequencing

| PRJNA607612 | ENA

Project description:Helicoverpa DNA methylation dynamics

| PRJNA1037564 | ENA

DNA methylation dynamics during pregnancy

Project description:DNA methylation dynamics during pregnancy

| PRJNA930683 | ENA

Project description:long-read transcriptome analysis from the Pacific abalone Haliotis discus hannai

| PRJNA522620 | ENA

Project description:transcriptome analysis of microRNA in the Pacific Abalone, Haliotis discus hannai

| PRJNA492758 | ENA

Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues (ChIP-Seq and MeDIP-Seq)

Project description:DNA methylation has been comprehensively profiled in normal and cancer cells, but the dynamics that form, maintain and reprogram differentially methylated regions remain enigmatic. We show that methylation patterns within populations of cells from individual somatic tissues are heterogeneous and polymorphic. Using in vitro evolution of immortalized fibroblasts for over 300 generations, we track the dynamics of polymorphic methylation at regions developing significant differential methylation on average. The data indicate that changes in population-averaged methylation occur through a stochastic process that generates a stream of local and uncorrelated methylation aberrations. Despite the stochastic nature of the process, nearly deterministic epigenetic remodeling emerges on average at loci that lose or gain resistance to methylation accumulation. Changes in the susceptibility to methylation accumulation are correlated with changes in histone modifications and CTCF occupancy. Characterizing epigenomic polymorphism within cell populations is therefore critical for understanding methylation dynamics in normal and cancer cells. Genomewide sequencing data is included herein: H3K27me3 profiled throughout the microevolutionary timecourse using ChIP-seq, DNA methylation profiled through the timecourse using MeDIP-seq, and H3K4me3 and CTCF profiled in late and early timepoints using ChIP-seq. Deep Bisulfite sequencing amplicon data and results can be obtained at: http://compgenomics.weizmann.ac.il/tanay/?page_id=99 .

2012-09-24 | E-GEOD-41048 | biostudies-arrayexpress

GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation (ChIPmentation)

Project description:Background: Hepatocytes comprise a major cell type of the human liver and function for metabolism, detoxification, and production of secreted proteins. During the hepatocyte differentiation process, whereas the gene regulation and master transcription factors have been extensively investigated, little is known about the epigenome regulation, particularly DNA methylation dynamics, and their responsible upstream factors. Results: Examining changes in transcriptome and methylome during in vitro hepatocyte differentiation, we identified putative DNA methylation-regulating transcription factors, which are likely involved in DNA demethylation and hypo-methylation maintenance in a differentiation stage-specific manner.

2022-05-04 | GSE163330 | GEO

GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation (DE ATAC-Seq)

2022-05-04 | GSE163327 | GEO