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New genetic biomarkers to differentiate pathogenic and clinically relevant Bacillus cereus strains

ABSTRACT: New genetic biomarkers to differentiate pathogenic and clinically relevant Bacillus cereus strains

PROVIDER: PRJNA718492 | ENA |

REPOSITORIES: ENA

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			Action	DRS
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	SRR14102603_1.fastq.gz	Fastqsanger.gz
	SRR14102603_2.fastq.gz	Fastqsanger.gz
	SRR14102607_1.fastq.gz	Fastqsanger.gz
	SRR14102607_2.fastq.gz	Fastqsanger.gz

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New genetic biomarkers to differentiate pathogenic and clinically relevant Bacillus cereus strains

Project description:Bacillus cereus is the second leading cause of collective food poisoning in France. B. cereus is also associated with severe clinical infections leading to patient death in 10% of the cases. The emergence of B. cereus as a foodborne and opportunistic pathogen has intensified the need to distinguish strains of public health concern. In this work, by performing a screen on a large collection of B. cereus strains of varying pathogenic potential, we identified genetic determinants capable of discriminating B. cereus strains inducing negative clinical outcomes. The combination of 4 biomarkers is sufficient to accurately discern clinical strains from harmless strains. Three of the biomarkers are located on the chromosome, with a fourth one identifying a plasmid carried by most pathogenic strains. A 50 kbp region of this plasmid promotes the virulence potential of these strains and could thus be defined as a new pathogenicity island of B. cereus. These new findings help in the understanding of B. cereus pathogenic potential and complexity and may provide tools for a better assessment of the risks associated with B. cereus contamination to improve patient health and food safety.

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