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Single-cell transcriptome analysis of Myt1l mutant mouse cortices at birth.

ABSTRACT: Single-cell transcriptome analysis of Myt1l mutant mouse cortices at birth.

PROVIDER: PRJNA719238 | ENA |

REPOSITORIES: ENA

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Single-cell transcriptome analysis of Myt1l mutant mouse cortices at birth.

Project description:We examined the effect of Myt1l deficiency in the cortices of mice at birth on the single cell level. Homozygous Myt1l deficiency resulted in postnatal lethality, and mutant mice presented increased expression of non-neuronal genes in neurons.

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MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention

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