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Transcriptional profiling of Bone Marrow Derived Dendritic Cells (BMDC) stimulated with zymosan or bacterial spent medium

ABSTRACT: Transcriptional profiling of Bone Marrow Derived Dendritic Cells (BMDC) stimulated with zymosan or bacterial spent medium

PROVIDER: PRJNA720419 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14168435_1.fastq.gz	Fastqsanger.gz
	SRR14168435_2.fastq.gz	Fastqsanger.gz
	SRR14168436_1.fastq.gz	Fastqsanger.gz
	SRR14168436_2.fastq.gz	Fastqsanger.gz
	SRR14168437_1.fastq.gz	Fastqsanger.gz

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Transcriptional profiling of Bone Marrow Derived Dendritic Cells (BMDC) stimulated with zymosan or bacterial spent medium

Project description:We reported transcriptional characterization of BMDCs stimulated by filter-sterilized spent medium of Parabacteroides goldsteinii ASF519 (ASF519 SSM) alone or in comination with zymosan. We identified that ASF519 SSM-induced differentially expressed genes have a wide association with the regulation of immune functions, cell communication, apoptosis. We observed that ASF519 SSM induced transcriptomic changes towards immune tolerance, such as a dramatic induction of tolerogenic Il10, lipocalin-2(Lcn2) and indoleamine 2, 3-dioxygenases (Ido1/2), and a reduction of the co-stimulatory molecule Cd40 and inflammatory cytokines, including Il12b, Il23a, and Il1f9 (or Il-36 gamma).

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