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Genomic-Wide Transcriptomic Analysis of the Forebrain of postnatal Slc13a4+/- mice

ABSTRACT: Genomic-Wide Transcriptomic Analysis of the Forebrain of postnatal Slc13a4+/- mice

PROVIDER: PRJNA720843 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14195351_1.fastq.gz	Fastqsanger.gz
	SRR14195351_2.fastq.gz	Fastqsanger.gz
	SRR14195352_1.fastq.gz	Fastqsanger.gz
	SRR14195352_2.fastq.gz	Fastqsanger.gz
	SRR14195353_1.fastq.gz	Fastqsanger.gz

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Genomic-Wide Transcriptomic Analysis of the Forebrain of postnatal Slc13a4+/- mice

Project description:We performed bulk RNA-seq on Nas2Del +/- Het and wild type postnatal Day 20 mice on samples collected from the mouse forebrain.

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Genome-wide transcriptomic analysis of the forebrain of postnatal Slc13a4<sup>+/-</sup> mice.

Project description:ObjectiveSulfation is an essential physiological process that regulates the function of a wide array of molecules involved in brain development. We have previously shown expression levels for the sulfate transporter Slc13a4 to be elevated during postnatal development, and that sulfate accumulation in the brains of Slc13a4+/- mice is reduced, suggesting a role for this transporter during this critical window of brain development. In order to understand the pathways regulated by cellular sulfation within the brain, we performed a bulk RNA-sequencing analysis of the forebrain of postnatal day 20 (P20) Slc13a4 heterozygous mice and wild-type litter mate controls.Data descriptionWe performed an RNA transcriptomic based sequencing screen on the whole forebrain from Slc13a4+/- and Slc13a4+/+mice at P20. Differential expression analysis revealed 90 differentially regulated genes in the forebrain of Slc13a4+/- mice (a p-value of 0.1 was considered as significant). Of these, 55 were upregulated, and 35 were downregulated in the forebrain of heterozygous mice. Moreover, when we stratified further with a ± 1.2 fold-change, we observed 38 upregulated, and 16 downregulated genes in the forebrain of heterozygous mice. This resource provides a useful tool to interrogate which pathways may require elevated sulfate levels to drive normal postnatal development of the brain.

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2016-06-22 | E-GEOD-82356 | biostudies-arrayexpress

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Project description:We sequenced mRNA from mouse brain to compare gene expression level between 2 forebrain and 2 cerebellum.

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ChIP-seq from forebrain (ENCSR070MOK)

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