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TRAP-seq of VMH Nr5a1 neurons

ABSTRACT: TRAP-seq of VMH Nr5a1 neurons

PROVIDER: PRJNA722419 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14252348.fastq.gz	Fastqsanger.gz
	SRR14252349.fastq.gz	Fastqsanger.gz
	SRR14252350.fastq.gz	Fastqsanger.gz
	SRR14252351.fastq.gz	Fastqsanger.gz
	SRR14252352.fastq.gz	Fastqsanger.gz

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TRAP-seq of VMH Nr5a1 neurons

Project description:To identify transcripts enriched in ventomedial hypothalamus (VMH) neurons, we used translating affinity ribosome purification combined with RNA-seq (TRAP-seq) from Nr5a1-Cre mice.

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TRAP-seq of VMH Lepr neurons

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TRAP-seq of VMH Lepr neurons

Project description:To identify transcripts enriched in ventomedial hypothalamus (VMH) Lepr neurons, we used translating affinity ribosome purification combined with RNA-seq (TRAP-seq) from Lepr-Cre mice.

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TRAP-seq of VMH Lepr∩Slc17a6 neurons

Project description:To identify transcripts enriched in ventomedial hypothalamus (VMH) neurons that contain both Lepr and Slc17a6, we used translating affinity ribosome purification combined with RNA-seq (TRAP-seq) from Lepr-Cre;Slc17a6-Flpo mice.

2021-05-19 | GSE172202 | GEO

TRAP-seq of VMH Lepr∩Slc17a6 neurons

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Central Amygdala TRAP-Seq of Drd2 neurons

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TRAP-seq of NTS/AP Calcr neurons

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Gene expression in mouse ventromedial hypothalamus (VMH) after deletion of SIRT1 in SF1 neurons

Project description:VMH was dissected from 16-week-old mice with deletion of SIRT1 in SF1 neurons (Sf1-Cre; Sirt1loxP/loxP) and intact controls (Sirt1loxP/loxP) and fed on high calorie diet from 8 weeks of age.

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Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance

Project description:Background: Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Methods: We combined mouse genetics, electrophysiology, neural tracing, optogenetics and Patch-RNA-seq to demonstrate how glucose-sensing neurons in the ventrolateral VMH regulate glucose balance. Results: Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) are glucose-sensing neurons to a 5-1-5mM glucose fluctuation, being glucose-inhibited neurons (GI-ERαvlVMH) or glucose-excited neurons (GE-ERαvlVMH). Hypoglycemia activates GI-ERαvlVMH neurons via the anoctamin 4 channel, and inhibits GE-ERαvlVMH neurons through opening the ATP-sensitive potassium channel. Further, we show that GI-ERαvlVMH neurons preferentially project to the medioposterior arcuate nucleus of the hypothalamus (mpARH) and GE-ERαvlVMH neurons preferentially project to the dorsal Raphe nuclei (DRN). Activation of ERαvlVMH-mpARH circuit and inhibition of ERαvlVMH-DRN circuit both increase blood glucose. Conclusions: Our results indicate that ERαvlVMH neurons detect glucose fluctuations and prevent severe hypoglycemia in mice.

2020-04-01 | GSE146543 | GEO

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