Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cx43 in Cdh5+ cells maintains blood-brain barrier integrity by NAD+ during aging

ABSTRACT: Cx43 in Cdh5+ cells maintains blood-brain barrier integrity by NAD+ during aging

PROVIDER: PRJNA723191 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14279707_1.fastq.gz	Fastqsanger.gz
	SRR14279707_2.fastq.gz	Fastqsanger.gz
	SRR14279708_1.fastq.gz	Fastqsanger.gz
	SRR14279708_2.fastq.gz	Fastqsanger.gz
	SRR14279709_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Cx43 in Cdh5+ cells maintains blood-brain barrier integrity by NAD+ during aging

Project description:Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how it can be prevented. Using single-nucleus transcriptomics, we identified decreased connexin 43 (CX43) expression in Cadherin-5+ (Cdh5+) cerebral vascular cells in naturally aging mice and confirmed it in human brain samples. Global or Cdh5+ cell-specific CX43 deletion in mice exacerbated BBB dysfunction during aging. The CX43-dependent effect was not due to its canonical gap junction function but was associated with reduced NAD+ levels and mitochondrial dysfunction through NAD+-dependent sirtuin 3. CX43 interacts with and negatively regulates poly (ADP-ribose) polymerase 1 (PARP1). Pharmacologic inhibition of PARP1 by olaparib or nicotinamide mononucleotide supplementation rescued NAD+ levels and alleviated aging-associated BBB leakage. These findings establish the endothelial CX43-PARP1-NAD+ pathway’s role in vascular aging and identify a potential therapeutic strategy to combat aging-associated BBB leakage with neuroprotective implications.

2021-04-21 | GSE172382 | GEO

Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport

Project description:Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport

| PRJNA1040298 | ENA

Autophagy maintains intestinal stem cell integrity

Project description:Autophagy maintains intestinal stem cell integrity

| PRJNA564106 | ENA

Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis

Project description:Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis

| PRJNA338316 | ENA

Hormone-responsive Bmpr1a maintains myoepithelial integrity during pregnancy

Project description:Hormone-responsive Bmpr1a maintains myoepithelial integrity during pregnancy

| PRJNA691166 | ENA

BRCA1 maintains telomere integrity through suppression of TERRA RNA and TERRA R-loop-induced DNA damage

Project description:Data in support of Vohhodina et al. "BRCA1 maintains telomere integrity through suppression of TERRA RNA and TERRA R-loop-induced DNA damage"

2021-04-21 | MSV000087276 | MassIVE

STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes

Project description:STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes

| PRJNA699446 | ENA

SRSF2 transcriptional function maintains genome integrity during cell division

Project description:SRSF2 transcriptional function maintains genome integrity during cell division

| PRJNA914312 | ENA

DNA methylation maintains integrity of higher order genome architecture

Project description:DNA methylation maintains integrity of higher order genome architecture

| PRJNA663616 | ENA

DNA methylation maintains integrity of higher order genome architecture (Nanopore)

Project description:DNA methylation maintains integrity of higher order genome architecture (Nanopore)