Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcript analysis of hESC-derived neurons treated with maturation promoting compounds

ABSTRACT: Transcript analysis of hESC-derived neurons treated with maturation promoting compounds

PROVIDER: PRJNA723602 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14295985_1.fastq.gz	Fastqsanger.gz
	SRR14295985_2.fastq.gz	Fastqsanger.gz
	SRR14295986_1.fastq.gz	Fastqsanger.gz
	SRR14295986_2.fastq.gz	Fastqsanger.gz
	SRR14295987_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Transcript analysis of hESC-derived neurons treated with maturation promoting compounds

Project description:High-content screening identified compounds that promote maturation of human neurons derived from pluripotent stem cells. We sequenced total RNA from neurons treated with these drugs to detemrine their effect at the transcriptome level.

2022-06-03 | GSE172544 | GEO

Gene expression analysis upon exposure of hESCs to novel set of self-renewal and differentiation compounds

Project description:Here we present a strategy to adapt hESCs to high-throughput screening (HTS) conditions, resulting in an assay suitable for the discovery of small molecules that drive hESC self-renewal or differentiation. Use of this new assay has led to the identification of several currently marketed drugs and natural compounds promoting short-term hESC maintenance and compounds directing early lineage choice. Global gene expression analysis upon drug treatment reveals overlapping and novel pathways correlated to hESC self-renewal and differentiation. Our results demonstrate feasibility of hESC-based HTS and enhance the available repertoire of chemical compounds for manipulating hESC fate. Keywords: Global gene expression analysis, drug response, human ES cells, pluripotency, differentiation, self-renewal

2008-06-05 | GSE11302 | GEO

Strobilurins as growth-promoting compounds: How Stroby regulates Arabidopsis leaf growth

Project description:Strobilurins as growth-promoting compounds: How Stroby regulates Arabidopsis leaf growth

| PRJEB18487 | ENA

High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

Project description:High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

2023-01-28 | GSE223599 | GEO

TMT characterisation: iPSC vs hESC

Project description:Detailed comparison of human pluripotent stem cells, to determine how hESC and iPSC differ in their protein expression profiles. The data was acquired in a TMT 10-plex SPS-MS3. 4 replicates of hESC compared to 4 replicates of HipSci human iPSCs.

2021-11-03 | PXD014502 | Pride

RNA-Seq to investigate the effect of small molecular compounds on the maturation capacity of monocyte-derived dendritic cells

Project description:Modulating beta-catenin signaling has attractive therapeutic potential in cancer immunotherapy. Various studies have found that beta-catenin can mediate immune evasion in cancer and promote anti-inflammatory features of antigen-presenting dendritic cells. Multiple small-molecule compounds that inhibit Wnt/beta-catenin signaling are currently in clinical development, but none have reached routine clinical use. Thus, new inhibitors of beta-catenin signaling are desirable. This dataset is the result of an investigation of the effect of small molecular compounds axitinib, ICG-001, nitazoxanide, orlistat, and XAV-939 on the maturation capacity of monocyte-derived dendritic cells (moDC). Treatment of immature moDC was done in combination with the beta-catenin activator 6-BIO. Immature moDCs were obtained by isolating monocytes from PBMC using magnetic beads, which were then differentiated into moDCs using GM-CSF and IL-4 for four days. Compounds were added during the maturation of the moDCs, which was done by adding LPS to the cell culture. After the maturation period of 24 hours, the mature moDCs were collected and processed for RNA sequencing.

2021-08-06 | E-MTAB-10757 | biostudies-arrayexpress

RNA-seq (Illumina and PacBio) of hESC

Project description:We used PacBio data to identify more reliable transcripts from hESC, based on which we can estimate gene/transcript abundance better from Illumina data. PacBio long reads and Illumina short reads were generated from the same hESC cell line H1. PacBio reads were error-corrected by Illumina reads to identify transcripts. rSeq is used to estimate gene/transcript abundance of the identified transcriptome.

2013-10-30 | E-GEOD-51861 | biostudies-arrayexpress

RNA-seq (Illumina and PacBio) of hESC

Project description:We used PacBio data to identify more reliable transcripts from hESC, based on which we can estimate gene/transcript abundance better from Illumina data.

2013-10-30 | GSE51861 | GEO

hESC neural differentiation

Project description:hESC neural differentiation

| PRJNA282596 | ENA

Genome wide transcript and miRNAanalysis of invitro and in-vivo generated human cardiac samples

Project description:We report the identification of miRNAs and transcripts that are regulated during human cardiac maturation. Examination of hESC-derived cardiomyocytes , human fetal tissue and human adult heart tissue for cardiomyocyte maturation.

2015-05-12 | E-GEOD-62913 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data