Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt) on gene expression in the brains of mouse neonates

ABSTRACT: Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt) on gene expression in the brains of mouse neonates

PROVIDER: PRJNA723811 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14300076_1.fastq.gz	Fastqsanger.gz
	SRR14300076_2.fastq.gz	Fastqsanger.gz
	SRR14300077_1.fastq.gz	Fastqsanger.gz
	SRR14300077_2.fastq.gz	Fastqsanger.gz
	SRR14300078_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 14

Similar Datasets

Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt) on H3K36me3 patterns in the brains of mouse neonates

Project description:Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt) on H3K36me3 patterns in the brains of mouse neonates

| PRJNA723812 | ENA

Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt) on H3K36me3 patterns in the brains of mouse neonates

Project description:We report that only a limited genes have differential H3K36me3 marks in the brains of heterozygous Setd2SRI/wt mice compared to those of wild type mice at P0.

2021-09-08 | GSE173092 | GEO

Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt) on gene expression in the brains of mouse neonates

Project description:We report that only a limited number of genes are differentially expressed in the brains of heterozygous Setd2SRI/wt mice compared to those of wild type mice at P0.

2021-09-08 | GSE173090 | GEO

Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt)

Project description:Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt)

| PRJNA723806 | ENA

Impact of heterozygous SRI mutation (R2483H) of Setd2 (Setd2SRI/wt)

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-08 | GSE173093 | GEO

Effects of Sorcin (SRI) overexpression on mouse pancreatic beta cells transcriptome

Project description:Pancreatic beta cells use electrical signals to couple changes in blood glucose concentration to insulin release via extracellular calcium (Ca2+) influx. Sorcin (SRI) is a Ca2+-binding protein whose overexpression in cardiomyocytes rescues the abnormal contractile function of the diabetic heart. In order to investigate the role of sorcin in regulating mouse pancreatic beta cell transcriptome, transgenic mice were generated on a C56BL/6 background permitting inducible overexpression of SRI cDNA with the TetOn-system specifically in beta cells. Animals bearing ten copies of the SRI transgene (SRI-tg10), and littermate controls, were fed a high fat diet (60% fat, HFD) and exposed to doxycycline in the drinking water (500mg/L) from 4 weeks onwards. Microarray analysis were performed using total RNA from isolated pancreatic islets of 8-week-old mice.

2015-09-09 | E-GEOD-72719 | biostudies-arrayexpress

SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B-cell lymphomagenesis

Project description:SETD2 is the sole chromatin modifier responsible for H3K36me3, a histone mark linked to splicing, transcription initiation and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 mutation is virtually always heterozygous in diffuse large B-cell lymphomas (DLBCL). Here we show that heterozygous SETD2 deficiency results in germinal center (GC) hyperplasia and accelerated lymphomagenesis. SETD2 haploinsufficient GC B-cells exhibit increased competitive fitness and reduced DNA damage checkpoint activity, resulting in decreased apoptosis. SETD2 haploinsufficient GCB and lymphoma cells featured increased off- and on-target AICDA induced somatic hypermutation (SHM), complex structural variants such as rygma, and increased translocations including those activating MYC. DNA damage was selectively increased on the non-template strand and H3K36me3 loss was associated with greater RNA Pol II processivity and mutational burden, suggesting that SETD2-mediated H3K36me3 is required for proper sensing of cytosine deamination during transcription. Hence, SETD2 haploinsufficiency delineates a novel GC B-cell context specific oncogenic pathway involving defective epigenetic surveillance of AICDA mediated somatic hypermutation induced off target effects on transcribed genes.

2022-04-06 | GSE189867 | GEO

Proteomics analysis on SETD2 loss induced ccRCC formation

Project description:Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important tumor suppressor gene in ccRCC. However, the role of SETD2 in tumorigenesis during the transition from PKD to ccRCC remains largely unexplored. Herein, we performed metabolomics, lipidomics, transcriptomics and proteomics with SETD2 loss induced PKD-ccRCC transition mouse model. To characterize biological responses triggered by SETD2 deletion during PKD-ccRCC transition at the protein level, we conducted global proteomics studies.

2023-10-31 | PXD038966 | Pride

RNA sequencing of SETD2 isogenic renal cell carcinoma cell lines

Project description:RNA sequencing of SETD2 isogenic renal cell carcinoma cell lines. Examination of RNA expression in SETD2 isogenic cell lines

2015-06-17 | E-GEOD-66879 | biostudies-arrayexpress

Setd2 knockdown.

Project description:Setd2 knockdown.

| PRJNA612891 | ENA