Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tetrastigma hemsleyanum

ABSTRACT: Tetrastigma hemsleyanum Transcriptome or Gene expression

PROVIDER: PRJNA725615 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14366934_1.fastq.gz	Fastqsanger.gz
	SRR14366934_2.fastq.gz	Fastqsanger.gz
	SRR14366935_1.fastq.gz	Fastqsanger.gz
	SRR14366935_2.fastq.gz	Fastqsanger.gz
	SRR14366936_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Transcriptome or Gene expression

| PRJNA880648 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Assembly

| PRJNA607847 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Assembly

| PRJNA607850 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum overview

| PRJNA608044 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum clean data

| PRJNA826914 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Raw sequence reads

| PRJNA827014 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Raw sequence reads

| PRJNA1001142 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Genome sequencing and assembly

| PRJNA725161 | ENA

Tetrastigma hemsleyanum

Project description:Tetrastigma hemsleyanum Genome sequencing and assembly

| PRJNA704788 | ENA

Tetrastigma hemsleyanum Polysaccharides Alleviate Imiquimod-Induced Psoriasis-Like Skin Lesions in Mice by Modulating the JAK/STAT3 Signaling Pathway

Project description:Crosstalk between keratin-forming cells and aberrant immune cells due to immune imbalance is a key factor in the pathogenesis of psoriasis. Most of the current clinical treatments provide rapid symptomatic relief but bring side effects that should not be ignored. Tetrastigma hemsleyanum polysaccharides (THP) have significant immunomodulatory and anti-inflammatory properties. In this study, we used imiquimod (IMQ)-induced psoriasis mouse model and LPS/IL-6-stimulated HaCaT cell model. The potential and mechanism of action of THP for psoriasis treatment were assessed by Psoriasis Area Severity Index (PASI) score, histopathology, flow cytometry, Western blot, and reverse transcription-polymerase chain reaction. The signs and symptoms of psoriatic mice induced by IMQ were significantly relieved by percutaneous administration of THP, including the improvement of psoriatic skin signs (erythema, folds, scales), pathological changes, decreased PASI score, and decreased spleen index. Results of in vivo and in vitro studies suggest that THP inhibits abnormal cell proliferation and excessive inflammation at skin lesions, balances Th17 immune cells, and blocks the keratinocyte-Th17 cell cycle, thus playing a role in psoriasis treatment by a mechanism that may be related to the regulation of the JAK/STAT3 signaling pathway.

2024-05-03 | GSE266043 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data