Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide maps of ERα-DNA binding events

ABSTRACT: Genome-wide maps of ERα-DNA binding events

PROVIDER: PRJNA726433 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14368886.fastq.gz	Fastqsanger.gz
	SRR14368887.fastq.gz	Fastqsanger.gz
	SRR14368888.fastq.gz	Fastqsanger.gz
	SRR14368889.fastq.gz	Fastqsanger.gz
	SRR14368890.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Genome-wide maps of ERα-bound RNAs and ERα-DNA binding events

Project description:Genome-wide maps of ERα-bound RNAs and ERα-DNA binding events

| PRJNA726424 | ENA

Genome-wide maps of ERα-DNA binding events

Project description:To identify WT and RNA-binding-domain-mutated (RBDmut) ERα binding sites on DNA, we performed ChIP-seq of FLAG-tagged ERα.

2021-08-01 | GSE173629 | GEO

Genome-wide maps of ERα-bound RNAs.

Project description:Genome-wide maps of ERα-bound RNAs.

| PRJNA726432 | ENA

Genome-wide maps of ERα-bound RNAs.

Project description:To identify Estrogen receptor α (ERα) binding sites on RNAs, we performed HITS-CLIP of endogenous ERα.

2021-08-01 | GSE173628 | GEO

Genome-wide maps of ERα-bound RNAs and ERα-DNA binding events

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-08-01 | GSE173631 | GEO

Genome-wide maps of HHEX binding

Project description:Genome-wide maps of HHEX binding

| PRJNA615887 | ENA

Genome-wide maps of SP100A binding chromatin.

Project description:Genome-wide maps of SP100A binding chromatin.

| PRJNA784407 | ENA

Genome-wide maps of ISL1-binding site

Project description:Genome-wide maps of ISL1-binding site

| PRJNA503335 | ENA

Genome-Wide Analysis of Estrogen Receptor-α DNA Binding and Tethering Mechanisms

Project description:The nuclear receptor, estrogen receptor alpha (ERα), controls the expression of hundreds of genes responsible for target cell phenotypic properties, but the relative importance of direct vs. tethering mechanisms of DNA binding has not been established. In this first report, we examine the genome-wide chromatin localization of an altered-specificity mutant ER with a DNA-binding domain deficient in binding to estrogen response element (ERE)-containing DNA (DBDmut ER) vs. wild type ERα. Using high-throughput sequencing of ER chromatin immunoprecipitations (ChIP-Seq) and mRNA transcriptional profiling, we show that direct ERE binding is required for most (75%) estrogen-dependent gene regulation and 90% of hormone-dependent recruitment of ER to genomic binding sites. De novo motif analysis of the chromatin binding regions in MDA-MB-231 human breast cancer cells defined unique transcription factor profiles responsible for genes regulated through tethering vs. direct DNA (ERE) binding, with Runx motifs enriched in ER-tethered sites. We confirmed a role for Runx1 in mediating ERa genomic recruitment and regulation of tethering genes. Our findings delineate the contributions of ERE binding vs. binding through response elements for other transcription factors in chromatin localization and ER-dependent gene regulation, paradigms likely to underlie the gene regulatory actions of other nuclear receptors as well. This SuperSeries is composed of the following subset Series: GSE22593: WT and DBDmut Breast Cancer Cells GSE22609: Genome-Wide Maps of WT and DBDmut Estrogen Receptor in Human Breast Cancer Cells Refer to individual Series

2010-06-29 | E-GEOD-22610 | biostudies-arrayexpress

Genome-wide mapping of ligand-dependent ERα binding sites in the ERα AF-2 mutant mouse uterus

Project description:Genome-wide mapping of ligand-dependent ERα binding sites in the ERα AF-2 mutant mouse uterus

| PRJNA564792 | ENA