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The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [RAW264.7]

ABSTRACT: The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [RAW264.7]

PROVIDER: PRJNA727351 | ENA |

REPOSITORIES: ENA

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The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [RAW264.7]

Project description:We report RNA sequencing data that shows the differential effects of HLA-DRb1*0301 (LE), HLA-DRb1*0401 (SE) and HLA-DRb1*0402 (PE) on macrophage gene expression under IFNγ cell culture conditions.

2022-08-03 | GSE173875 | GEO

The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [THP-1]

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The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope

Project description:The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope

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The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [THP-1]

Project description:The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [THP-1]

| PRJNA727352 | ENA

The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-03 | GSE173877 | GEO

New Allele HLA-DRB1*03

Project description:Sample od DVMO Brasil, with new allele HLA-DRB1*03.

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The HLA-DRB1*03:01 ligandome is highly conserved on N- and C-terminal residues outside the peptide-binding cleft

Project description:Human CD4+ T lymphocytes play an important role in inducing potent immune responses. They are activated and stimulated by peptides presented in Major Histocompatibility Complex Class II molecules. These MHC class II molecules typically present peptides of between 12 and 20 amino acids in length. The region that interacts with the MHC molecule, designated as the binding core, is highly conserved in the residues which anchor the peptide to the molecule. In addition, as these peptides are the product of proteolytic cleavages, certain conserved residues may be expected at the N- and C-termini outside the binding core. To study whether similar conserved residues are present in different types of cells , the ligandomes of HLA-DRB1*03:01 derived from two different cell types (dendritic cells and EBV-transformed B-cells) were identified with mass spectrometry and the binding core and N- and C-terminal residues were analysed using the frequencies of the amino acids in the human proteome. Similar binding motifs were found as well as comparable conservations in the N- and C-terminal residues. Furthermore, these terminal conservations of the HLA-DRB1*03:01 ligandome were compared to the N- and C-terminal conservations of the HLA-DRB1*04:01 ligandome acquired from dendritic cells. Again, comparable conservations were evident with only minor differences. Taken all together, these analyses show that there are conservations in the terminal residues of peptides, presumably the result of the activity of proteases involved in antigen processing.

2019-09-16 | PXD014253 | Pride

RAW264.7 cells versus H.pylori infected RAW264.7 cells

Project description:RAW264.7 cells versus H.pylori infected RAW264.7 cells

| PRJNA635395 | ENA

New Allele HLA-DRB1

Project description:HLA-DRB1*11:04 new

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RAW264.7 cells versus H.pylori infected RAW264.7 cells

Project description:Comparing gene expression in the RAW264.7 cells before and after H. pylori infection at MOI 10 for 24 hours

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