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Aortic gene expression profiles of double ApoE and ApoA-I knockout mice

ABSTRACT: Aortic gene expression profiles of double ApoE and ApoA-I knockout mice

PROVIDER: PRJNA727791 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14457410.fastq.gz	Fastqsanger.gz
	SRR14457411.fastq.gz	Fastqsanger.gz
	SRR14457412.fastq.gz	Fastqsanger.gz
	SRR14457413.fastq.gz	Fastqsanger.gz
	SRR14457414.fastq.gz	Fastqsanger.gz

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Project description:The goal of this study is to determine whether A1 adenosine receptor (ADORA1) plays a role in atherosclerosis development and its possible mechanisms. This dataset compares gene expression (aortas) of ADORA1 knockout mice to ADORA1+APOE double-knockout mice. Mice deficient in both ADORA1 and APOE (DKO) demonstrated reduced atherosclerotic lesions in aortic arch (en face), aortic root, and innominate arteries when compared to (APOE-KO) of the same age. Treating APOE-KO with the ADORA1 antagonist DPCPX also achieved concentration-dependent reduction in lesions. The total plasma cholesterol and triglyceride levels were not different between DKO and APOE-KO, however, higher triglyceride was observed in DKO fed a high-fat diet. DKO also were heavier than APOE-KO. Plasma cytokine levels (IL-5, IL-6, and IL-13) were significantly lower in DKO. Proliferating cell nuclear antigen (PCNA) expression was also significantly reduced in the aorta from DKO. Despite smaller lesions in DKO, the composition of the innominate artery lesions and cholesterol loading and effusion [export] from bone-marrow-derived macrophages from DKO were not different from APOE-KO.

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Aortic gene expression profiles of double ApoE and ApoA-I knockout mice

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