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MiR-138 controls interneuron function and short-term memory

ABSTRACT: miR-138 controls interneuron function and short-term memory

PROVIDER: PRJNA727797 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14457465_1.fastq.gz	Fastqsanger.gz
	SRR14457465_2.fastq.gz	Fastqsanger.gz
	SRR14457466_1.fastq.gz	Fastqsanger.gz
	SRR14457466_2.fastq.gz	Fastqsanger.gz
	SRR14457467_1.fastq.gz	Fastqsanger.gz

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miR-138 controls interneuron function and short-term memory

Project description:Using a miR-138 loss-of-function mouse model, a role for the brain enriched microRNA miR-138 in the regulation of inhibitory synaptic transmission and short-term memory formation was shown.

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MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice.

Project description:The proper development and function of neuronal circuits rely on a tightly regulated balance between excitatory and inhibitory (E/I) synaptic transmission, and disrupting this balance can cause neurodevelopmental disorders, for example, schizophrenia. MicroRNA-dependent gene regulation in pyramidal neurons is important for excitatory synaptic function and cognition, but its role in inhibitory interneurons is poorly understood. Here, we identify miR138-5p as a regulator of short-term memory and inhibitory synaptic transmission in the mouse hippocampus. Sponge-mediated miR138-5p inactivation specifically in mouse parvalbumin (PV)-expressing interneurons impairs spatial recognition memory and enhances GABAergic synaptic input onto pyramidal neurons. Cellular and behavioral phenotypes associated with miR138-5p inactivation are paralleled by an upregulation of the schizophrenia (SCZ)-associated Erbb4, which we validated as a direct miR138-5p target gene. Our findings suggest that miR138-5p is a critical regulator of PV interneuron function in mice, with implications for cognition and SCZ. More generally, they provide evidence that microRNAs orchestrate neural circuit development by fine-tuning both excitatory and inhibitory synaptic transmission.

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A Thalamic Orphan Receptor Drives Variability in Short Term Memory

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Fractionated Proton Irradiation does not Impair Hippocampal Dependent Short Term or Spatial Memory in Female Mice

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A Thalamic Orphan Receptor Drives Variability in Short Term Memory

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Short-term cold exposure induces persistent epigenomic memory in brown fat

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