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ABSTRACT: Gingival health study

PROVIDER: PRJNA728740 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14487251_1.fastq.gz	Fastqsanger.gz
	SRR14487251_2.fastq.gz	Fastqsanger.gz
	SRR14487252_1.fastq.gz	Fastqsanger.gz
	SRR14487252_2.fastq.gz	Fastqsanger.gz
	SRR14487253_1.fastq.gz	Fastqsanger.gz

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Transcription profiling of human gingival epithelial cell transcriptional responses to commensal and opportunistic oral microbial species.

Project description:Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral commensal S. gordonii and the opportunistic commensal F. nucleatum. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral commensal S. gordonii (Sg) or the opportunistic commensal F. nucleatum (Fn). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to commensals, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of health in the mixed bacterial-human ecosystem of the oral cavity.

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Project description:Analysis of response to leptin and IL-1β in gingival fibroblasts at the gene expression level. The hypothesis tested in the present study was that leptin and IL-1β synergistically effect the phenotype of gingival fibroblasts. Results provide important information regarding the response of gingival fibroblasts to leptin and IL-1β, such as specific inflammatory genes that were up- or down-regulated.

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Project description:Human Variation in Gingival Inflammation (HVGI) Study

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