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FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons [TRAP-seq, RNA-seq]

ABSTRACT: FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons [TRAP-seq, RNA-seq]

PROVIDER: PRJNA729259 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14507210_1.fastq.gz	Fastqsanger.gz
	SRR14507210_2.fastq.gz	Fastqsanger.gz
	SRR14507211_1.fastq.gz	Fastqsanger.gz
	SRR14507211_2.fastq.gz	Fastqsanger.gz
	SRR14507212_1.fastq.gz	Fastqsanger.gz

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FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons [TRAP-seq, RNA-seq]

Project description:We report cell-type and compartment-specific TRAP-seq, RNAseq, FMRP-CLIP, and PAPERCLIP from CA1 hippocampal neurons. We use TRAP-seq and PAPERCLIP data to precisely define the dendritic transcriptome, including mRNAs that harbor APA and AS events that are differentially localized. Further, we use FMRP-CLIP in order to define mRNAs that undergo compartment-specific regulation by FMRP.

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FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

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