Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ethoxysanguinarine, Baicalin, Gastrodin and Valsartan treatment lower Angiotensin-II-induced blood pressure

ABSTRACT: Ethoxysanguinarine, Baicalin, Gastrodin and Valsartan treatment lower Angiotensin-II-induced blood pressure

PROVIDER: PRJNA729720 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14521900_1.fastq.gz	Fastqsanger.gz
	SRR14521900_2.fastq.gz	Fastqsanger.gz
	SRR14521901_1.fastq.gz	Fastqsanger.gz
	SRR14521901_2.fastq.gz	Fastqsanger.gz
	SRR14521902_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 60

Similar Datasets

Ethoxysanguinarine, Baicalin, Gastrodin and Valsartan treatment lower Angiotensin-II-induced blood pressure

Project description:The goals of this study is to identify the differential expressed genes in abdominal aorta of C57BL/6 mice with or without Angiotensin II (AngII) treatment, and compare the differential expressed genes in the abdominal aorta of Ang II infused C57BL/6 mice after Ethoxysanguinarine (ETH), Baicalin (BAI), Gastrodin (GAS) or valsartan (VAL) treatment. Briefly, the mice (n=30) were randomly divided into 6 groups: control, AngII, AngII + ETH, AngII + BAI, AngII + GAS and AngII + VAL groups (n=5 for each group). Mice in Control and AngII groups were infused with saline and 500 ng/kg/min of AngII respectively, and orally administrated with saline; the mice in AngII + ETH, AngII + BAI and AngII + GAS groups were infused with AngII (500 ng/kg/min) and orally administrated with 5 mg/kg /day of ETH, BAI or GAS daily for total 4 weeks. The mice in AngII + VAL group were infused with AngII (500 ng/kg/min) and orally administrated with 10.4mg/kg /day of VAL. Then the abdominal aortas were used to identify differentially expressed genes among different groups.

2021-05-14 | GSE174386 | GEO

RNA sequencing to detect the differentially expressed genes in AngII infused mice after Ethoxysanguinarine, Baicalin, Gastrodin or Valsartan treatment

Project description:The goals of this study is to identify the differential expressed genes in cardiac tissue of C57BL/6 mice with or without Angiotensin II (AngII) treatment, and compare the differential expressed genes in the cardiac tissue of Ang II infused C57BL/6 mice after Ethoxysanguinarine (ETH), Baicalin (BAI), Gastrodin (GAS) or valsartan (VAL) treatment. Briefly, the mice (n=30) were randomly divided into 6 groups: control, AngII, AngII + ETH, AngII + BAI, AngII + GAS and AngII + VAL groups (n=5 for each group). Mice in Control and AngII groups were infused with saline and 500 ng/kg/min of AngII respectively, and orally administrated with saline; the mice in AngII + ETH, AngII + BAI and AngII + GAS groups were infused with AngII (500 ng/kg/min) and orally administrated with 5 mg/kg /day of ETH, BAI or GAS daily for total 4 weeks. The mice in AngII + VAL group were infused with AngII (500 ng/kg/min) and orally administrated with 10.4mg/kg /day of VAL. Then the cardiac tissues were used to identify differentially expressed genes among different groups.

2023-01-09 | GSE193504 | GEO

RNA sequencing to detect the differentially expressed genes in AngII infused mice after Ethoxysanguinarine, Baicalin, Gastrodin or Valsartan treatment

Project description:RNA sequencing to detect the differentially expressed genes in AngII infused mice after Ethoxysanguinarine, Baicalin, Gastrodin or Valsartan treatment

| PRJNA796422 | ENA

Quercetin treatment lower Angiotensin-II-induced blood pressure

Project description:The goals of this study is to compare the differently expressed genes in renal tissue of C57BL/6 WT mice with or without Angiotensin II (AngII) treatment as well as differently expressed genes in the renal tissue of WT mice with AngII treatment with or without Quercetin (Que) treatment. The mice (n=18) were randomly divided into 3 groups: control, AngII,AngII+ Que (n=6 for each group). Mice in Control and AngII groups were infused with saline or 500 ng/kg/min of AngII respectively, and intragastrically with double distilled water (dd H2O); while mice in AngII + Que groups were infused with AngII (500 ng/kg/min) and intragastrically with 5mg/kg/D of Que for 4 weeks. Then the renal tissue were used to identify differentially expressed genes among different groups.

2022-07-15 | GSE207102 | GEO

Qingda granules lower Angiotensin-II-induced blood pressure

Project description:The goals of this study is to compare the differently expressed genes in abdominal aorta of C57BL/6 WT mice with or without Angiotensin II (AngII) treatment as well as differently expressed genes in the abdominal aorta of WT mice with AngII treatment with or without Qingda granules (QDG) treatment. The mice (n=15) were randomly divided into 3 groups:control, AngII and QDG treated (n=5 for each group). Mice in Control and AngII groups were infused with saline or 500 ng/kg/min of AngII respectively, and orally administrated with saline; while mice in AngII + QDG group were infused with AngII (500 ng/kg/min) and orally administrated with 1.145 g/kg /day of QDG for 2 weeks. Then the abdominal aorta were used to identify differentially expressed genes among different groups.

2021-01-28 | GSE165601 | GEO

Quercetin treatment lower Angiotensin-II-induced blood pressure

Project description:Quercetin treatment lower Angiotensin-II-induced blood pressure

| PRJNA853738 | ENA

Qingda granules lower Angiotensin-II-induced blood pressure

Project description:Qingda granules lower Angiotensin-II-induced blood pressure

| PRJNA695212 | ENA

Transcriptome analysis of basal and luminal cells treatment with baicalin

Project description:Baicalin is the main flavonoid component extracted from Scutellaria root. It has multiple potent biological activities, including estrogen-like activity. In our study, we investigated the function of baicalin on mammary stem cell proliferation and mammary development. Our results demonstrated that baicalin significantly accelerates mammary gland development at puberty and during pregnancy; In vitro, baicalin significantly promotes colony formation ability of mammary basal epithelial cells in a three-dimensional (3D) culture system; In vivo, baicalin improved mammary regeneration efficiency in mouse xenograft model. But the mechanism was unknown. Therefore, transcriptome analysis of basal and luminal cells treatment with baicalin was performed.

2021-02-05 | GSE166157 | GEO

Qingda granule（QDG） treatment lower Angiotensin-II-induced blood pressure

Project description:The goals of this study is to compare the differently expressed genes in renal tissue of C57BL/6 WT mice with or without Angiotensin II (AngII) treatment as well as differently expressed genes in the renal tissue of WT mice with AngII treatment with or without Qingda granule（QDG）treatment. The mice (n=15) were randomly divided into 3 groups: control, AngII,AngII+ QDG (n=5 for each group). Mice in Control and AngII groups were infused with saline or 500 ng/kg/min of AngII respectively, and intragastrically with double distilled water (dd H2O); while mice in AngII + QDG groups were infused with AngII (500 ng/kg/min) and intragastrically with 1.145 g/kg/D of QDG for 4 weeks. Then the renal tissue were used to identify differentially expressed genes among different groups.

2022-03-02 | GSE182517 | GEO

Qingda granule（QDG） treatment lower Angiotensin-II-induced blood pressure

Project description:Qingda granule（QDG） treatment lower Angiotensin-II-induced blood pressure

| PRJNA756553 | ENA