Project description:Inhibition of the MIA pathway of mitochindrial protein import by targeting ALR depletes mitochondrial Cox17 and induces differentiation in AML cells
Project description:Stromal fibroblast cells were isolated from an unusually enlarged left-side ovary of a Holstein cow. Isolated stromal cells expressed several genes such as asporin and VCAM1 that are active in aggressive tumors. Several functional pathways were modulated especially sirutin signaling pathway, oxidative phosphorylation and mitochindrial dysfunction.