Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: key genes of giant congenital melanocytic nevi

PROVIDER: PRJNA730598 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14573500_1.fastq.gz	Fastqsanger.gz
	SRR14573500_2.fastq.gz	Fastqsanger.gz
	SRR14573501_1.fastq.gz	Fastqsanger.gz
	SRR14573501_2.fastq.gz	Fastqsanger.gz
	SRR14573502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Genetic Abnormalities in Large to Giant Congenital Nevi: Beyond NRAS mutations

Project description:Large and giant congenital melanocytic nevi (CMN) are rare melanocytic lesions mostly caused by post-zygotic acquisition of NRAS alteration. However, large/giant CMN may exhibit phenotypic differences among distinct areas patients and in addition, patients differ in features such as presence of multiple CMN or Spilus-like lesions. Overall, 50 fresh-frozen biopsies corresponding to 37 phenotypically characterized areas of large/giant CMNs, 9 satellite lesions, 1 acquired nevus and 3 healthy skin biopsies were analyzed by a multigene panel and RNA sequencing (RNA-seq). Mutational screening showed mutations in 76.2% of large/giant CMN. NRAS mutation was found in 57.1% of cases, and mutations in other genes such as BRAF, KRAS, APC and MET were detected in 14.3% of patients. RNA-seq revealed the fusion transcript ZEB2-ALK and SOX5-RAF1 in large/giant CMN from two patients without point mutations. Both alterations were not detected in unaffected skin and were detected in different affected skin. These findings suggest that large/giant CMN may result from distinct molecular events in addition to NRAS mutations including point mutations and fusions transcripts.

2019-10-24 | GSE120597 | GEO

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

Project description:Congenital melanocytic nevi (CMN) and common acquired melanocytic nevi (AMN) are skin conditions that result from an excess of melanocytes arising during fetal development or detected postnatally. Appropriately weighted whole-genome methylation analysis can be used as a basis for further research in dermatopathology and, in this application, provides new insights into nevus biology.

2024-06-17 | GSE268769 | GEO

Homo sapiens

Project description:Genetic profiles of large/giant congenital melanocytic nevi with familial or sporadic occurrence.

| PRJNA977656 | ENA

Giant congenital nevi exome sequencing

Project description:Characterization of the genomic landscape of giant congenital nevi.

| EGAS00001004541 | EGA

The role of SOX10 in human melanoma

2012-07-03 | GSE37059 | GEO

Acral Melanoma microRNA Ratio Classification

Project description:We performed microRNA sequencing of primary human FFPE Acral Melanoma (AM), Cutaneous Melanoma (CM), Acral Nevi (AN), and Cutaneous Nevi (CN). We found that previously identified ratios of microRNAs, particularly miR-21-5p and miR-211-5p, were able to accurately classify benign and malignant melanocytic neoplasia, both in non-acral cutaneous melanomas and nevi (CM vs CN), as well as matched acral melanoma and nevi (AM vs AN). Receiver operating characteristic area under the curve (AUC) of Ensemble models trained using these microRNA ratios demonstrated AUCs of 0.88-0.90 across these melanoma subtypes, suggesting the potential utility of these ratios as a biomarker of malignancy in melanocytic neoplasia.

2024-08-14 | GSE266413 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq, RNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2020-05-22 | GSE150849 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2021-05-13 | GSE174371 | GEO

Progressive immune activation and negative immunoregulation from common melanocytic nevi to dysplastic nevi to melanoma

Project description:The purpose of this study was to comprehensively study and compare the molecular gene expression profiles of common melanocytic nevi (GSE53223), dysplastic nevi (GSE53223), and primary melanoma.

2018-10-25 | GSE114445 | GEO

The role of SOX10 in human melanoma

Project description:We have shown that Sox10 plays a crucial role in the initiation and maintenance of giant congenital nevi and melanoma in a mouse model of melanoma.To dissect the molecular mechanisms and analyze the role of SOX10 in the maintenance of human melanoma, we have performed microarray study. Human melanoma cell line M010817 was transfected with either control shRNA or SOX10 shRNA. RNA was isolated at 48 hours and 96 hours after transfection and subjected to hybridization on Affymetrix microarrays.

2012-07-02 | E-GEOD-37059 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data