Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mentored Patient Oriented Research in Lymphoma

ABSTRACT: Mentored Patient Oriented Research in Lymphoma

PROVIDER: PRJNA730943 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Mentored Patient Oriented Research in Lymphoma

Project description:Mentored Patient Oriented Research in Lymphoma

| PRJNA730944 | ENA

Pediatric Leukemia and Lymphoma patient stool microbiome

Project description:Pediatric Leukemia and Lymphoma patient stool microbiome

| PRJEB53954 | ENA

Human lymphoma cell membrane proteomics by Pitchfork strategy

Project description:We combined glycopeptide enrichment by SPEG (Tian et al., 2007) with a hydrophobic segment-oriented hpTC method (Vít et al 2016) and a standard “detergent and trypsin” approach into a tree-pronged “Pitchfork” strategy for the analysis of membrane proteome in human lymphoma cells.

2019-03-29 | PXD012647 | Pride

circRNA-sequencing of a lymph node in a primary effusion lymphoma patient

Project description:Total RNA was extracted from a lymph node of a primary effusion lymphoma patient and treated with Rnase R to degrade linear, but not circular, RNA followed by deep-sequencing (PE150).

2021-06-30 | GSE165525 | GEO

Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine

Project description:Background Follicular lymphoma (FL), the most common indolent non-Hodgkin’s Lymphoma, is a heterogeneous disease and a paradigm of the contribution of immune tumor microenvironment to disease onset, progression, and therapy resistance. Patient-derived models are scarce and fail to reproduce immune phenotypes and therapeutic responses. Methods To capture disease heterogeneity and microenvironment cues, we developed a patient-derived lymphoma spheroid (FL-PDLS) model culturing FL cells from lymph nodes (LN) with an optimized cytokine cocktail that mimics LN stimuli and maintains tumor cell viability. Results FL-PDLS, mainly composed of tumor B cells (60% on average) and autologous T cells (13% CD4 and 3% CD8 on average, respectively), rapidly organizes into patient-specific three-dimensional (3D) structures of three different morphotypes according to 3D imaging analysis. RNAseq analysis indicates that FL-PDLS reproduces FL hallmarks with the overexpression of cell cycle, BCR, or mTOR signaling related gene sets. FL-PDLS also recapitulates the exhausted immune phenotype typical of FL-LN, including expression of BTLA, TIGIT, PD-1, TIM-3, CD39 and CD73 on CD3+ T cells. These features render FL-PDLS an amenable system for immunotherapy testing. With this aim, we demonstrate that the combination of obinutuzumab (anti-CD20) and nivolumab (anti-PD1) reduces tumor load in a significant proportion of FL-PDLS. Interestingly, B cell depletion inversely correlates with the percentage of CD8+ cells positive for PD-1 and TIM-3. Conclusions In summary, FL-PDLS is a robust patient-derived 3D system that can be used as a tool to mimic FL pathology and to test novel immunotherapeutic approaches in a context of personalized medicine.

2024-02-28 | GSE256457 | GEO

Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine

Project description:Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine

| PRJNA1079718 | ENA

Phosphoproteome of NSCLC patient–derived cells.

Project description:Phosphoproteome of anaplastic lymphoma kinase–positive non-small cell lung cancer (ALK+ NSCLC) patient–derived cells.

2024-11-19 | PXD050973 | JPOST Repository

Molecular classification of tumour cells in a patient with intravascular large B-cell lymphoma

Project description:Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal LBCL. It is characterized by the proliferation of tumour cells exclusively intraluminally in small blood vessels of different organs. We used microarray-based analysis of gene expression of tumour cells isolated from a patient with primary manifestation of the lymphoma in the skin and compared it with various other diffuse LBCLs (DLBCLs) as well as a previously published DLBCL classifier.

2017-11-15 | GSE106876 | GEO

meiose non oriented RNA-Seq data

Project description:meiose non oriented RNA-Seq data

| PRJEB5029 | ENA