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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection [RNA-seq dataset 2]

ABSTRACT: Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection [RNA-seq dataset 2]

PROVIDER: PRJNA731049 | ENA |

REPOSITORIES: ENA

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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection [RNA-seq dataset 1]

Project description:Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection [RNA-seq dataset 1]

| PRJNA731048 | ENA

Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection

Project description:Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection

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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection [RNA-seq dataset 2]

Project description:Dermal macrophages (Macs) are essential for the timely resolution of staphylococcal skin infections. However the cell intrinsic pathways and microenvironmental cues that mediate this are unclear. Here we analyzed a strictly intradermal ear infection model with Staphylococcus aureus (S. aureus) to explore immunometabolic regulation.

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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection [RNA-seq dataset 1]

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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-01 | GSE174676 | GEO

Staphylococcal isolates

Project description:WGS Staphylococcal isolates from PJI and Wounds

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In vitro Exon Level Expression Profiling of dermal fibroblast

Project description:Transcriptome analysis of of control inhibitor and miR200b inhibitor transfected Human Dermal Adult Fibroblasts (HDAF) compared with Human Dermal Microvascular Endothelial Cells (HMEC). Injury induced inhibition of miR200b induces angiogenesis at the wound edges which help in the healing process. We have characterised the effect of miR200b suppression in Human Adult Dermal Fibroblasts converts to endothelial cells through transcriptional profiling. In this dataset, we include the expression data obtained from control inhibitor and miR200b inhibitor transfected Human Dermal Adult Fibroblasts, as well as Human Dermal Microvascular Endothelial Cells (HMEC) as positive control.

2017-12-31 | GSE89715 | GEO

Translatome and transcriptome profiling of SH-SY5Y cells treated with staphylococcal alpha-hemolysin oligomers

2015-04-01 | GSE60543 | GEO

Translatome and transcriptome profiling of SH-SY5Y cells treated with staphylococcal alpha-hemolysin oligomers

Project description:Genome-wide analysis of translation has the potential to provide major contributions in understanding the pathophysiology of infection processes, given the complex interplay between pathogens and host cells. This study uncovers the reshaping undergoing in the translational control system of the host in response to staphylococcal α-hemolysin oligomers (rAHL). Keywords: translatome profiling, polysomal profiling, polysomal RNA, translational control, translational profiling, polysome profiling, post-transcriptional regulation, staphylococcal α-hemolysin, pore forming toxins, PTF. The comparison between translatome and transcriptome profiling was used to discover mRNA-specific changes of the SH-SY5Y cells transcriptome and translatome in response to staphylococcal α-hemolysin oligomers (rAHL). To identify translationally regulated mRNAs, gene expression signals derived from the polysomal mRNA populations were compared by microarrays analysis to those obtained from total RNAs. Polysomal mRNA and total mRNA were isolated from SH-SY5Y cells treated with 3nM of extracted oligomers (rAHL) for 2 hours. Cells lysates were collected from untreated cells (control) and from treated cells. All experiments were run in biological triplicates.

2015-04-01 | E-GEOD-60543 | biostudies-arrayexpress

Expression data obtained from primary dermal papilla cell cultures and human hair follicle organ culture from occipital scalp

Project description:In this dataset, we include the expression data obtained from primary dermal papilla cell cultures and human hair follicle organ culture from occipital scalp

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