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Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model

ABSTRACT: Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model

PROVIDER: PRJNA731874 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14614715_1.fastq.gz	Fastqsanger.gz
	SRR14614715_2.fastq.gz	Fastqsanger.gz
	SRR14614716_1.fastq.gz	Fastqsanger.gz
	SRR14614716_2.fastq.gz	Fastqsanger.gz
	SRR14614717_1.fastq.gz	Fastqsanger.gz

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Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model [polyA-RNA-seq]

Project description:DNA damage can promote altered RNA splicing and decreased gene expression (Gregersen and Svejstrup, 2018; Milek et al., 2017; Munoz et al., 2009; Shkreta and Chabot, 2015), and aberrant splicing is implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Fragile X syndrome and spinal muscular atrophy (SMA) (Conlon et al., 2016; Jia et al., 2012; Loomis et al., 2014; Qiu et al., 2014; Scotti and Swanson, 2016). Therefore, we used RNA-seq data to assess RNA-splicing in double-mutant brain tissue using multivariate analysis of transcriptional splicing (rMATS) (Shen et al., 2014) and a splicing deficiency score algorithm (Bai et al., 2013) to assess intron retention.

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Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-14 | GSE174842 | GEO

Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model [Total_PolII_Chip-seq]

Project description:Alterations in RNA Polymerase II kinetics can affect key co-transcriptional processes such as normal splicing and transcript elongation and can influence nonsense mediated decay (Fong et al., 2014; Jonkers and Lis, 2015). Specific types of DNA damage can variably influence RNA Pol II activity. We performed Total RNA Pol ll ChIP-seq to investigate how the chronic DNA damage can affect RNA Pol ll activity in the cerebellum tissues.

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