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LCMV-Armstrong infection

ABSTRACT: LCMV-Armstrong infection

PROVIDER: PRJNA733467 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14676300_1.fastq.gz	Fastqsanger.gz
	SRR14676300_2.fastq.gz	Fastqsanger.gz
	SRR14676301_1.fastq.gz	Fastqsanger.gz
	SRR14676301_2.fastq.gz	Fastqsanger.gz
	SRR14676302_1.fastq.gz	Fastqsanger.gz

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Gene expression profile analysis of mouse whole spleen following infection by lymphocytic choriomeningitis virus (LCMV), comparing LCMV-Armstrong and LCMV-Clone 13 expression patterns at 0, 5, 9, and 30 days

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mRRBS analysis of C1qbp sufficient and deficient CD8+ T cells sorted from mice post infection with LCMV Armstrong

Project description:This study is aimed to explore whether C1qbp deficiency affects the DNA methylation status during the differentiation stage of CD8+ T cells. Transferred WT and C1qbp KO P14 cells sorted from the spleen of donor mice on day 5 post-infection with LCMV Armstrong were collected. Genomic DNA was isolated for mRRBS. mRRBS analysis provided evidence of DNA methylation changes between WT and C1qbp KO CD8+ T cells. Our study have shown that, on day 5 post-infection with LCMV Armstrong, C1qbp KO CD8+ T cells have increased level of Global DNA methylation. Moreover, C1qbp KO CD8+ T cells show hegher DNA methylation at some effector cells-signature genes.

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