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TGFβ signaling controls neural crest developmental plasticity via Smad2/3

ABSTRACT: TGFβ signaling controls neural crest developmental plasticity via Smad2/3

PROVIDER: PRJNA733779 | ENA |

REPOSITORIES: ENA

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TGFβ signaling controls neural crest developmental plasticity via Smad2/3

Project description:The neural crest is a highly plastic stem cell population that represents a notable exception to the germ layer theory. Despite being of ectodermal origin, these cells can differentiate into skeletal derivatives like cartilage and bone, tissues that are typically formed by mesoderm. The inductive program that endows the neural crest with these unique properties is still poorly understood. Here, we report that Smad2/3-mediated TGFβ signaling endows cranial neural crest cells with enhanced developmental potential. Our results show that TGFβ signaling modulates neural crest axial identity and directly activates the gene circuits that support skeletal differentiation. Cooperation between TGFβ and low levels of WNT-signaling in the embryonic head activates cranial-specific cis-regulatory elements of anterior genes. Activation of the TGFβ pathway allowed reprogramming of trunk neural crest cells to adopt an anterior identity and led to the development of an improved protocol for the generation of human cranial neural crest cells. Our findings indicate TGFβ signaling is required for the specification of cranial neural crest cells, endowing them with the potential to give rise to the craniofacial skeleton.

2025-01-19 | GSE175809 | GEO

TGFβ signaling controls neural crest developmental plasticity via Smad2/3

2025-01-19 | GSE175808 | GEO

TGFβ signaling controls neural crest developmental plasticity via Smad2/3

Project description:TGFβ signaling controls neural crest developmental plasticity via Smad2/3

| PRJNA733778 | ENA

TGFβ signaling controls neural crest developmental plasticity via Smad2/3

Project description:TGFβ signaling controls neural crest developmental plasticity via Smad2/3

| PRJNA733780 | ENA

TGFβ signaling controls neural crest developmental plasticity via Smad2/3 [ATAC-seq]

2025-01-19 | GSE278072 | GEO

TGFβ signaling controls neural crest developmental plasticity via Smad2/3 [RNA-seq]

2025-01-19 | GSE278071 | GEO

TGFβ signaling controls neural crest developmental plasticity via Smad2/3 [ATAC-seq]

Project description:TGFβ signaling controls neural crest developmental plasticity via Smad2/3 [ATAC-seq]

| PRJNA1165405 | ENA

TGFβ signaling controls neural crest developmental plasticity via Smad2/3 [RNA-seq]

Project description:TGFβ signaling controls neural crest developmental plasticity via Smad2/3 [RNA-seq]

| PRJNA1165404 | ENA

TGFβ signaling controls neural crest developmental plasticity via Smad2/3

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-18 | GSE175811 | GEO

Fibroblast-specific genetic dissection of TGFβ-Smad2/3 signaling in cardiac fibrosis

Project description:Overall goal: To elucidate fibroblast-specific role of TGFβ-Smad2/3 signaling in fibroblast activation and their differentiation to myofibroblasts. Purpose of analysis: To generate transcriptional profile of Smad2/3 and TGFβreceptors1/2-deficient fibroblasts in the context of pathological cardiac fibrosis.

2017-10-25 | GSE101772 | GEO

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