Project description:Arenaviruses infection during pregnancy can cause severe maternal disease, congenital infection, and/or fetal demise. Little is known about the pathogenesis of this family of viruses in the placenta because many are endemic in resource-poor regions and must be studied in high containment laboratories. Pichinde virus (PICV) is a nonpathogenic arenavirus that causes hemorrhagic fever-like disease in guinea pigs. In this study, we sought to assess whether PICV replicates in human trophoblasts and how infection affected pregnant guinea pigs. RNA-sequencing was done on PICV-infected human trophoblast stem cells and samples of placenta and decidua collected from infected and control pregnant guinea pigs.
2026-09-19 | GSE329765 | GEO
Project description:Whole-genome re-sequencing for guinea fowl (Numida meleagris).
| PRJNA639777 | ENA
Project description:MinION sequencing of avian influenza virus H1N3 in guinea fowl
Project description:With the purpose to elucidate the expression changes of host genes of SPF chickens infected with duck-origin H7N9 subtype avian influenza virus at 24 hours post-infection(hpi) and fowl adenovirus-4 at 48 dpi. The spleens of SPF chickens infected with duck-origin H7N9 subtype avian influenza virus and fowl adenovirus-4 were collected and high throughout sequenced. Compared with the control group, there were 2426 differentially expressed genes were obtained in the duck-origin H7N9 subtype avian influenza virus group, including 913 up-regulated genes and 1513 down-regulated genes, and there were 1534 differentially expressed genes were obtained in the fowl adenovirus-4 group, including 632 up-regulated genes and 902 down-regulated genes.
2020-06-03 | GSE151662 | GEO
Project description:DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples