Project description:A microarray analysis was conducted using the brain, heart, and liver tissues of mouse orally administrated aqueous extracts of Ephedra herba, in which the expression level of many genes were altered depending on the duration of treatment time. Aqueous extracts of Ephedra herba were administered orally for 1 hr, 6 hrs, 12 hrs, 24 hrs, 3 days, 5 days and 10 days on mice.
Project description:A microarray analysis was conducted using the brain tissue of mouse orally administrated aqueous extracts of Ephedra herba, in which the expression level of many genes were altered depending on the duration of treatment time. In particular, temporal changes in the expressions of genes can be classified into two major reciprocal patterns. Aqueous extracts of Ephedra herba were administered orally at dosage of 50 or 1,250 mg/kg once daily for 1, 3 and 10 consecutive days on mice. Expression level of genes from brain tissue was compared to that from untreated control mice.