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Human gut metagenome

ABSTRACT: Huangqi-Honghua combination regulates cerebral infarction with Qi deficiency and blood stasis syndrome rats the by autophagy pathway

PROVIDER: PRJNA736765 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14783957_1.fastq.gz	Fastqsanger.gz
	SRR14783957_2.fastq.gz	Fastqsanger.gz
	SRR14783958_1.fastq.gz	Fastqsanger.gz
	SRR14783958_2.fastq.gz	Fastqsanger.gz
	SRR14783959_1.fastq.gz	Fastqsanger.gz

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Transcriptomics reveals the molecular transcriptional regulatory network of Xinhuitong in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome

Project description:Research purpose: To explore the key targets and core signal pathways of XHT (Xinhuitong, XHT) in regulating coronary heart disease with Qi deficiency and blood stasis syndrome through transcriptomics, and reveal the transcriptional regulatory network of XHT in treating coronary heart disease with Qi deficiency and blood stasis syndrome. Research method: Using transcriptomics RNA-Seq technology, gene sequencing of myocardial tissues in the ischemic marginal zone of the Qi deficiency and blood stasis syndrome model group and the high-dose Yiqi Huoxue prescription group and searching for differential genes, from the perspective of gene regulation and expression patterns To study the possible effective drug targets and effect mechanism pathways of XHT in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome, and to further explore the treatment of coronary heart disease with Qi deficiency and blood by Chinese medicine compound prescriptions. The possible pharmacological mechanism of blood stasis syndrome, and the key molecular nodes and effect mechanism pathways suggested by it are verified by molecular biology methods.

2023-02-13 | GSE211248 | GEO

Multi-group analysis of TCM syndrome types of patients with colorectal cancer

Project description:Interventions: Patients with spleen deficiency and qi stagnation syndrome SDQSS:NA;Patients with DHS with damp-heat accumulation syndrome:NA;Patients with SPOS with stasis and internal resistance syndrome:NA;Patients with SKYDS of Spleen and Kidney Yang Deficiency Syndrome:NA;Patients with liver-kidney yin deficiency syndrome LKYDS:NA;QBDS patients with deficiency of both qi and blood syndrome:NA Primary outcome(s): Serum metabolites;Fecal microbiome;lipidomics Study Design: Diagnostic test for accuracy

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Quantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis

Project description:Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of cerebral infarction were used as the research object. The protein expression levels among the control group, Yiqi group and Huoxue Yiqi group were compared by non labeled quantitative proteomics technology. The difference of protein expression level was higher than 1.2 times as the significant difference. Compared with the control group, there were 120 differentially expressed proteins; Through bioinformatics analysis and biological function clustering of differentially expressed proteins, it is found that Yiqi recipe can regulate energy metabolism and nerve function and change hemorheology, while Yiqi Huoxue recipe can regulate energy metabolism, antithrombotic function and improve vascular function. This study explored the biological mechanism of Yiqi recipe and Huoxue Yiqi recipe in the protein level, which provided a molecular basis for the clinical treatment of CI-QDBS and the related research of traditional Chinese medicine.

2022-12-12 | PXD029388 |

Circulating mRNA Profiles Differ between Qi-Deficiency and Yin deficiency in Ischemic Stroke Rats with Blood Stasis Syndrome

Project description:Qi deficiency blood stasis (QDBS) and Yin deficiency blood stasis (YDBS) are the two major subtypes of which according to the traditional Chinese medicine. This study was conducted to distinguish these two syndromes at transcriptomics level and explore the underlying mechanisms.

2017-06-21 | GSE100235 | GEO

Bioinformatics analysis of transcriptome related to blood stasis syndrome in diabetes mellitus patients

Project description:In traditional Chinese medicine (TCM), blood stasis syndrome (BSS) is mainly manifested by the increase of blood viscosity, platelet adhesion rate and aggregation, and the change of microcirculation, resulting in vascular endothelial injury. It is an important factor in the development of diabetes mellitus (DM). According to the differences in the internal and external environment of the individual disease, BSS were divided into qi-deficiency and blood stasis syndrome (QDBS), qi-stagnation and blood stasis syndrome (QSBS), cold-coagulation and blood stasis syndrome (CCBS), heat-accumulation and blood stasis syndrome (HABS). The aim of this study was to screen out the potential candidate mRNAs in DM patients with BSS by high-throughput sequencing (HTS) and bioinformatics analysis. CRL-1730 human umbilical vein endothelial cells (HUVECs) were incubated with 10% human serum to establish models of DM with BSS, DM without BSS (NBS) and normal control (NC). Total RNA of each sample was extracted and sequenced by the Hiseq2000 platform. Differentially expressed mRNAs (DE-mRNAs) were screened between samples. On the basis of mRNA expression profiles, four comparisons were made, including QDBS vs NBS and NC, QSBS vs NBS and NC, CCBS vs NBS and NC, HABS vs NBS and NC. Then, comparisons with P values <0.05 (Fisher's exact test), false discovery rates (FDR) <0.01 and |log2 ratios|≥1 were considered as DE-mRNAs in BSS. This study screened out the DE-mRNAs in DM patients with BSS by HTS and bioinformatics analysis.

2018-04-03 | GSE109265 | GEO

Rattus norvegicus

Project description:Circulating mRNA Profiles Differ between Qi-Deficiency and Yin deficiency in Ischemic Stroke Rats with Blood Stasis Syndrome

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Mass spectrometry data of human urine

Project description:Based on UPLC-Q-TOF-MS metabolomics technology, urine samples of 1072 subjects from 9 centers, including normal control, phlegm and blood stasis (PBS) syndrome and Qi and Yin deficiency (QYD) syndrome, and other syndromes of CHD, were conducted to find biomarkers. Among them, the discovery set (n = 125) and the test set (n = 337) were used to identify and validate biomarkers, and the validation set (n = 610) was used for the application and evaluation of the support vector machine (SVM) prediction model.

2019-03-27 | PXD012910 | Pride

Effect of Supplementing Qi and strengthening spleen on the expression of TTR in serum of patients with colorectal carcinoma and its correlation with the dynamic changes of syndrome

Project description:Interventions: Syndrome of spleen qi deficiency1:Chinese medicine of Supplementing Qi and nourishing spleen;Syndrome of spleen qi deficiency2:no;Flat syndrome group:no;Qi deficiency constitution:no Primary outcome(s): Symptom score;Serum TTR expression Study Design: Case-Control study

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The intestinal microecology changes and metabonomics-based prognostic biomarkers screening in advanced colorectal cancer patients with qi deficiency syndrome

Project description:Interventions: Group1:Qi deficiency syndrome quantitative score>8;Group 2:Yin deficiency syndrome quantitative score>10;Group 3:deficiency syndrome quantitative score<3 with no obvious excess syndrome Primary outcome(s): serum metabonomics;Intestinal flora genome Study Design: Cohort study

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Application of gut microbiota in dynamic evaluation of TCM syndromes and canceration in patient with colorectal tumor

Project description:Interventions: Colorectal adenoma (excessive syndrome: intestinal damp-heat syndrome) group:None;Colorectal adenoma (deficiency syndrome: spleen and stomach deficiency syndrome) group:None;Colorectal cancer (excessive syndrome: damp-heat accumulation syndrome) group:None;Colorectal cancer (deficiency syndrome: spleen deficiency and qi stagnation syndrome) group:None;Healthy control group:None Primary outcome(s): Gut microbiota Study Design: Factorial

| 2741054 | ecrin-mdr-crc

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