Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Metagenomic next-generation sequencing for diagnosing infections in lung transplant recipients: A retrospective study

PROVIDER: PRJNA737316 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14866500.fastq.gz	Fastqsanger.gz
	SRR14866501.fastq.gz	Fastqsanger.gz
	SRR14866502.fastq.gz	Fastqsanger.gz
	SRR14866503.fastq.gz	Fastqsanger.gz
	SRR14866504.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 163

Similar Datasets

Project description:Metagenomic next-generation sequencing for diagnosing lung infections in lung transplant recipients

| PRJNA702899 | ENA

human metagenome

Project description:Metagenomic next-generation sequencing in viral infections of kidney transplant recipients

| PRJEB52278 | ENA

human urinary tract metagenome

Project description:Metagenomic next-generation sequencing in recurrent urinary tract infections of kidney transplant recipients

| PRJEB52041 | ENA

Microbiota and Complications in Kidney Transplant Recipients

Project description:<p>In this study, we investigated the role of the gut microbiota on the development of complications in kidney transplant recipients. We collected serial fecal specimens from 168 kidney transplant recipients within the first 3 months after transplantation. We performed 16S rRNA gene sequencing of the V4-V5 hypervariable region and examined whether the relative gut abundance of pathogenic bacteria was associated with future development of complications like bacteriuria and urinary tract infections. In a subset of samples, we performed metagenomic sequencing of stool and urine supernatant specimens to determine strain level analysis. </p>

| phs001879 | dbGaP

RNA-seq of bronchoalveolar lavage samples of lung transplant primary graft dysfunction

Project description:This is an RNA-seq study of human lung transplant recipients. Bronchoalveolar lavage cells were collected on the first day after lung transplant. We performed bulk RNA-sequencing on 19 lung transplant recipients with severe primary graft dysfunction (PGD) and 19 lung transplant recipients without primary graft dysfunction. As this data is human identifiable, raw data are not included in this record.

2023-02-15 | E-MTAB-12282 | biostudies-arrayexpress

human eye metagenome

Project description:Diagnosing corneal infections in formalin fixed specimens using next generation sequencing

| PRJNA381365 | ENA

Generation and persistence of human tissue-resident memory T cells in lung transplantation

Project description:Tissue resident memory T cells (TRM) maintain immunity in diverse sites as determined in mouse models, while their establishment and role in human tissues has been difficult to assess. Here, we investigated human lung TRM generation, maintenance and function in airway samples obtained longitudinally from HLA-disparate lung transplant recipients, where donor and recipient T cells could be localized and tracked over time. Donor T cells persist specifically in the lungs (and not blood) of transplant recipients and express high levels of TRM signature markers including CD69, CD103, and CD49a, while lung-infiltrating recipient T cells gradually acquire TRM phenotypes over months in vivo. Single cell transcriptome profiling of airway T cells reveals that donor T cells comprise two TRM-like subsets with varying levels of expression of TRM-associated genes while recipient T cells comprised non-TRM and similar TRM-like subpopulations, suggesting de novo TRM generation. Transplant recipients exhibiting higher frequencies of persisting donor TRM experienced fewer adverse clinical events such as primary graft dysfunction and acute cellular rejection compared to recipients with low donor TRM persistence, suggesting that monitoring TRM dynamics could be clinically informative. Together, our results provide novel spatial and temporal insights into how human TRM develop, function, persist, and impact tissue integrity within the complexities of lung transplantation.

2019-04-03 | GSE124675 | GEO

Project description:Lung microbiota in healthy lung transplant recipients

| PRJNA615630 | ENA

4f116e53-e722-4a09-ad23-6833dda7688a - samples

Project description:The TransplantLines Gut Microbiome study includes raw data generated by shotgun metagenomic sequencing of fecal samples of solid organ transplant recipients and basic phenotypes (age and sex, BMI).

| EGAD00001008907 | EGA

Project description:Lung and plasma viromes in lung transplant recipients

| PRJEB25186 | ENA